儿童呼吸道不可分型流感嗜血杆菌感染及耐药现状

发布时间：2017-12-28 13:34

本文关键词：儿童呼吸道不可分型流感嗜血杆菌感染及耐药现状　出处：《中华全科医学》2014年08期 　论文类型：期刊论文

【摘要】：目的了解孝感市中心医院儿童呼吸道不可分型流感嗜血杆菌感染现状及耐药性。方法对2010年1月—2012年12月门诊及住院呼吸道感染患儿的呼吸道标本进行细菌培养、菌种鉴定及药敏试验,并对结果进行统计、分析。结果 3573例呼吸道感染患儿共分离出不可分型流感嗜血杆菌105株:氨苄西林对产β-内酰胺酶的NTHi检出率为27.60%,3年产酶率依次为20.8%(5/24)、24.2%(8/33)、33.3%(16/48);NTHi对氯霉素、复方磺胺甲VA唑的耐药率较高,分别为16.19%、44.76%,而对阿奇霉素,二、三代头孢菌素及其复合制剂的敏感性均较高。结论不可分型流感嗜血杆菌的分离率、产酶率有逐年上升的趋势,耐药形势较为严峻,应引起临床高度重视。治疗以阿奇霉素,二、三代头孢菌素及其复合制剂为首选。
[Abstract]:Objective to investigate the infection status and drug resistance of Haemophilus influenzae in children's respiratory tract in Xiaogan Central Hospital. Methods bacterial culture, strain identification and drug sensitivity test of respiratory tract specimens from outpatients and hospitalized children with respiratory tract infection from January 2010 to December 2012 were conducted, and the results were statistically analyzed. Results 3573 cases of children with acute respiratory tract infection were isolated from nontypeable Haemophilus influenzae strains: 105 ampicillin on the production of beta lactamase positive rate of NTHi was 27.60%, the 3 annual rate of enzyme was 20.8% (5/24), 24.2% (8/33), 33.3% (16/48); NTHi resistant to chloramphenicol, trimethoprim sulfamethoxazole VA with the higher rate were 16.19%, 44.76%, and two or three generation cephalosporins of azithromycin, and the sensitivity of compound preparation were higher. Conclusion the rate of isolation and enzyme production of Haemophilus influenzae is increasing year by year, and the drug resistance situation is more severe, which should be paid more attention to. The treatment of azithromycin, the two or three generation cephalosporin and its compound preparation are the first choice.
【作者单位】：湖北省孝感市中心医院检验科;湖北省孝感市中心医院儿科;
【基金】：湖北省自然科学基金项目(2012FFC120)
【分类号】：R378.41;R446.5
【正文快照】： 流感嗜血杆菌(Haemophilus influenzae,Hi)是一类无芽胞、无棔毛、呈球杆状、长杆状、丝状等多形性的革兰阴性短小杆菌,流感嗜血杆菌一般有6种菌株,称为A型、B型(又称乙型)、C型、D型、E型及F型。大部分流感嗜血杆菌都是机会性感染细菌,B型流感嗜血杆菌(Hib)是引起儿童严重细

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