ApoE、HLA-DRB及ACE基因多态性与新疆和田地区维吾尔族自然长寿的相关性研究

发布时间：2017-12-30 23:36

本文关键词：ApoE、HLA-DRB及ACE基因多态性与新疆和田地区维吾尔族自然长寿的相关性研究　出处：《新疆医科大学》2005年博士论文　论文类型：学位论文

【摘要】：背景: 人类寿命是由环境因素与遗传基因共同作用而决定。关于环境因素与人类寿命的关系已有诸多研究,但对于遗传因素在人类寿命中的作用所知甚少。近年来,随着人类基因组学研究的进展,长寿的遗传学研究倍受关注。目前,科学家研究的焦点多集中在参与脂代谢、能量代谢和机体免疫调控相关的基因上,诸如血管紧张素转换酶(ACE)、载脂蛋白(ApoB,XpoE)、胆固醇酯转运蛋白、线粒体DNA多态性、人类白细胞Ⅱ类抗原(HLA-DRB,DQB)及肿瘤坏死因子等基因。然而,诸多专家的研究结果不尽一致,表现出明显的种族差异性。新疆和田地区维吾尔族百岁老人数量和人口相对比率都明显高于全国平均水平,国际自然医学会将和田地区列为世界四大长寿地区之一,并且,由于环境、生活特点及风俗习惯,生活在该地区的维吾尔族极少与外界通婚,人口流动性小,遗传漂变小,极少受医疗因素影响,属自生自灭状态,形成了极为难得的遗传隔离群,其长寿人群属于自然长寿。这就为我们鉴定长寿的相关基因、研究遗传因素与长寿的关系提供了极为宝贵和难得的资源。国外研究资料提示,百岁老人长寿主要与不患其他老年人易患的心脑血管病等多发病以及保持良好的机体免疫状态相关。所以研究与心脑血管病易感相关的ACE、ApoE基因及和免疫有关的HLA-DRB基因多态性与新疆和田地区维吾尔族自然长寿的关系,对识别人类长寿基因的研究有重要意义。
[Abstract]:Background:
Human life is by environmental factors and genetic interaction and decision. Existing on the relation between environment factors and human life in many studies, but the genetic role in life expectancy is poorly understood. In recent years, with the progress of human genome research, genetics of longevity has attracted much attention. At present, the focus of scientific research focus on participation in lipid metabolism, energy metabolism and immune regulation of gene related, such as angiotensin converting enzyme (ACE), apolipoprotein (ApoB, XpoE), cholesteryl ester transfer protein, mitochondrial DNA polymorphism of human leucocyte antigen (HLA-DRB, DQB) and tumor necrosis factor gene however, many experts and the research results are not consistent, showing significant racial differences.
Xinjiang Hetian Uygur centenarian population number and relative ratios are significantly higher than the national average, the Hotan region as one of the four major regions of the world, life and the environment, international natural medicine life characteristics and customs, Uygur nationality living in the region with little outside marriage, population mobility. Genetic drift is small, there are few medical factors, is formed as a emerge of itself and perish of itself, rare genetic isolates, the longevity crowd belongs to natural longevity. This is our identification of genes related to longevity, the relationship between genetic factors and longevity research provide an extremely valuable and rare resources.
The foreign research data suggest that centenarian longevity and not suffering from other elderly people susceptible to cardiovascular disease and other diseases and maintain good immune status. So the study of cardiovascular disease susceptibility and related ACE, relationship between Uygur natural longevity related gene HLA-DRB and ApoE gene and immune state and Xinjiang Hetian area, has important significance for the recognition of human longevity genes.

【学位授予单位】：新疆医科大学
【学位级别】：博士
【学位授予年份】：2005
【分类号】：R394

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