人白细胞介素8治疗性疫苗的研制

发布时间：2018-01-22 08:28

本文关键词： 白细胞介素8 炎症性疾病单克隆抗体治疗性疫苗模拟表位筛选急性肺损伤　出处：《第四军医大学》2005年博士论文　论文类型：学位论文

【摘要】：白细胞介素8是一种趋化因子,属于趋化因子家族的C-X-C类。它不仅能选择性诱导中性粒细胞、T淋巴细胞和嗜碱性粒细胞趋化,还可增强中性粒细胞的功能,诱导中性粒细胞脱颗粒,释放颗粒中的各种酶类。除了促炎症效应外,IL-8还有促血管生成作用。IL-8在许多疾病的发生、发展过程中起着重要的作用,如:类风湿性关节炎、缺血再灌注损伤、各种肺部疾病以及肿瘤等。针对IL-8的治疗方法在动物模型和临床试验中已经取得了良好的效果,在LPS诱导的ARDS动物模型中,抗IL-8单克隆抗体能够防止ARDS的发生,明显提高了兔子的存活率;抗IL-8单克隆抗体用于治疗慢性阻塞性肺疾病(COPD)已经进入临床试验,临床Ⅱ期的试验结果表明该抗体应用于人体是安全的,并可以改善病人的呼吸困难的症状。利用抗IL-8单克隆抗体来治疗肿瘤如:乳腺癌、黑色素瘤、膀胱癌等也在动物体内取得了良好效果。虽然针对人类自身蛋白的单克隆抗体在治疗急、慢性疾病的过程中显示出了良好的效果,但是,造价的昂贵和使用上的不便限制了单克隆抗体的广泛应用,因此,由被动地接受这种抗体蛋白转向寻求针对人类自身蛋白的主动免疫疫苗成为蛋白质药物的发展方向之一。目前,治疗性疫苗的
[Abstract]:Interleukin-8 (IL-8) is a chemokine belonging to the C-X-C family of chemokines. It not only selectively induces neutrophil T lymphocytes and basophil chemotaxis. It can also enhance the function of neutrophils, induce the degranulation of neutrophils and release all kinds of enzymes in the granules. IL-8 also promotes angiogenesis. IL-8 plays an important role in the development of many diseases, such as rheumatoid arthritis, ischemia-reperfusion injury. A variety of lung diseases and tumors. The treatment of IL-8 in animal models and clinical trials have achieved good results in LPS induced ARDS animal model. Anti IL-8 monoclonal antibody can prevent the occurrence of ARDS and improve the survival rate of rabbits. Anti IL-8 monoclonal antibody used in the treatment of chronic obstructive pulmonary disease (COPD) has entered the clinical trial, clinical stage II test results show that this antibody is safe in human body. It can also improve the symptoms of dyspnea. The use of anti IL-8 monoclonal antibodies to treat tumors such as breast cancer, melanoma, bladder cancer and so on has also achieved good results in animals. Although monoclonal antibodies against human self proteins have shown good results in the treatment of acute and chronic diseases, however. The high cost and inconvenience of use limit the wide application of monoclonal antibodies. From passively accepting this antibody protein to seeking an active immune vaccine against human own protein, it has become one of the developing directions of protein drugs.
【学位授予单位】：第四军医大学
【学位级别】：博士
【学位授予年份】：2005
【分类号】：R392.1

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