人脑基底神经节微血管的形态计量学研究

发布时间：2018-02-22 07:44

本文关键词： 微血管构筑基底神经节人脑形态计量学　出处：《山西医科大学》2005年硕士论文　论文类型：学位论文

【摘要】：目的:脑内微血管的结构及其定量研究是研究脑微循环动力学变化规律和调节机制的基础,对阐明脑血管疾患的病理学机制具有极其重要的意义。而近年来研究发现,中枢神经组织内移植转基因组织的存活和生长与其周围血管构筑也有密切关系。因此本文对人脑基底神经节内的微血管构筑及形态计量学进行了观察研究,为脑微循环研究积累资料,为进一步研究脑循环生理学、病理学提供形态学资料和有关参数。材料与方法:采用死亡不超过 24 小时的一岁半幼儿(8 例)新鲜脑标本,经固定、火棉胶包埋、组织切片、碱性磷酸酶染色、光镜观察及体视学处理,对其尾状核、壳核、苍白球、屏状核、杏仁核及内囊内的微血管密度进行定量分析,并对其微血管进行了定性研究。结果:(1)基底神经节各核团内的微动脉有两种类型即微长动脉和微短动脉。其走行迂曲, 形态各异。(2)基底神经节内各结构的毛细血管吻合成网。不同神经组织内血管网形态各异,不同神经组织内血管密度存在显著差异,其微血管密度由高到低依次为壳核、尾状核、屏状核、杏仁核、苍白球、内囊。基底神经节的壳核、尾状核、屏状核内血管网形态相似且较密,网孔较小。杏仁核、苍白球的血管网形态较相似且较稀疏,网孔较大,但杏仁核比苍白球密。内囊中微血管分布多与神经纤维走行方向一致,其管径较粗,网孔较大。
[Abstract]:Objective: the structure and quantitative study of cerebral microvasculature are the basis of studying the changes of cerebral microcirculation dynamics and regulating mechanism, and are of great significance in elucidating the pathological mechanism of cerebrovascular diseases. The survival and growth of transgenic tissues in central nervous tissue are also closely related to the vascular architecture around them. Therefore, the microvascular architecture and morphometrics in the basal ganglion of human brain were observed and studied in this paper. To accumulate data for the study of cerebral microcirculation and to provide morphological data and related parameters for further study of cerebral circulation physiology and pathology. Materials and methods: fresh brain samples were fixed in 8 cases of children aged one and a half years who died less than 24 hours. The microvessel density of caudate nucleus, putamen nucleus, globus pallidus, platelike nucleus, amygdaloid nucleus and internal capsule were quantitatively analyzed by microvessel embedding, tissue section, alkaline phosphatase staining, light microscopic observation and stereological treatment. The microvessels were qualitatively studied. Results there were two types of arterioles in the basal ganglia nuclei: long arterioles and short arterioles. The arterioles were tortuous and varied in shape) capillaries in the basal ganglia. The vascular networks in different nerve tissues are different in shape. There were significant differences in the density of blood vessels between different nerve tissues. The microvessel density in the putamen nucleus, caudate nucleus, plateliform nucleus, amygdaloid nucleus, globus pallidus, internal capsule, putamen nucleus of basal ganglia, caudate nucleus, In the amygdala, the vascular network of the globus pallidus is similar and sparse, but the amygdala is denser than the globus pallidus, and the microvessel distribution in the inner capsule is more consistent with the direction of the nerve fibers. The diameter of the pipe is larger and the mesh is larger.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2005
【分类号】：R322

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