西藏藏族人群多个红细胞血型系统基因多态性研究

发布时间：2018-02-28 00:11

本文关键词： 红细胞血型基因多态性西藏藏族　出处：《中国输血杂志》2014年05期 　论文类型：期刊论文

【摘要】：目的了解西藏藏族人群RhCE、MNS、Duffy、Kell、Dombrock、Diego、Kidd、Scianna、Colton和Lutheran 10个红细胞血型系统的基因多态性特点。方法采用PCR-SSP方法对409名西藏藏族RhD(+)献血者10个血型系统进行基因分型。结果西藏藏族人群RHCE血型系统基因频率为:C=0.573 3,c=0.426 7,E=0.365 5,e=0.634 5;MNS血型基因频率为:M=0.680 9,N=0.319 1,S=0.146 7,s=0.853 3;Duffy血型Fya和Fyb的基因频率分别为0.921 8,0.078 2;Dombrock血型基因频率为:Doa=0.1504,Dob=0.849 6;Diego血型基因频率为:Dia=0.034 2,Dib=0.965 8;Kidd血型基因频率为:Jka=0.551 3,Jkb=0.448 7;血型基因频率为:Coa=0.997 6,Cob=0.002 4;Lutheran血型系统基因频率为:Lua=0,Lub=1.000 0;Aua=0.910 8,Aub=0.089 2。409名献血者Kell血型和Scianna血型均为纯合子,基因型为k/k和Sc1/Sc1。结论西藏藏族人群RhCE、MNS、Kidd和Dombrock血型系统具有其独特的分布特点;Duffy、Diego、Lutheran和Colton血型系统基因分布与国内其他人群相似;Kell、Scianna呈单态性分布,符合中国人群分布特点。
[Abstract]:Objective to investigate the RhCE, Duffy, MNS in Tibetan population in Tibet, Kell, Dombrock, Diego, Kidd, Scianna, Colton and Lutheran gene polymorphisms of 10 red blood cell system. Methods PCR-SSP of 409 Tibet Tibetan RhD (+) blood donors 10 blood group system was 3.77%. The results of gene frequency Tibet Tibetan population RHCE blood group system: C=0.573 3, c=0.426 7, E=0.365 5, e=0.634 5; MNS blood group gene frequency: M=0.680 9, N=0.319 1, S=0.146 7, s=0.853 3; gene frequency of Duffy blood group Fya and Fyb were 0.921 8,0.078 2; Dombrock blood group gene frequency: Doa=0.1504, Dob=0.849 6; Diego gene frequency: Dia=0.034 2, Dib=0.965 8; Kidd blood group gene frequency: Jka=0.551 3, Jkb=0.448 7; gene frequency: Coa=0.997 6, Cob=0.002 4; gene frequency of Lutheran blood group system: Lua=0 Lub=1.000 0; Aua=0.910 8, Aub=0.089 2.409 Blood donors Kell and Scianna blood type were homozygous genotypes RhCE, k/k and Sc1/Sc1. conclusion of Tibetan population in Tibet MNS, Kidd and Dombrock blood group system has its unique distribution characteristics; Duffy, Diego, Lutheran and Colton blood group gene distribution and other domestic similar populations; Kell, Scianna distributes monomorphic, with Chinese population distribution characteristics.

【作者单位】：中国医学科学院北京协和医学院输血研究所;西藏自治区血液中心;
【分类号】：R457.1

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