游离脂肪酸对正常成人促肾上腺皮质激素及皮质醇分泌的影响

发布时间：2018-03-06 14:44

本文选题：游离脂肪酸　切入点：皮质醇　出处：《重庆医科大学》2006年硕士论文　论文类型：学位论文

【摘要】： 目的:了解游离脂肪酸对正常成人促肾上腺皮质激素、皮质醇基础分泌及昼夜节律的影响。方法:6名正常青年男性志愿者作为受试者,行自身前后对照,随机先后接受20%脂肪乳-肝素(简称LHE组)和生理盐水-肝素(简称SH组)输入,时间为51小时,二次试验间隔一周以上。测定血糖、游离脂肪酸(FFAs)、促肾上腺皮质激素(ACTH)和皮质醇。比较两组受试者不同时间点血浆ACTH和皮质醇的基础分泌量及其昼夜节律。结果:1、第一天上午(8am-11am)LHE组和SH组血糖比较无统计学意义,但第二、三天上午(8am-11am),LHE组血糖明显高于SH组(P=0.022,P=0.005)。2、试验开始60分钟后,LHE组血浆FFAs水平明显高于SH组(P0.001),直至试验结束。3、第一天上午(8am-11am)LHE组血浆ACTH水平明显低于SH组(P=0.048),但第二、三天上午,两组比较无统计学意义。4、第一天上午(8am-11am)LHE组血浆皮质醇水平明显低于SH组(P=0.042),但第二、三天上午,两组比较无统计学意义。5、SH组和LHE组血浆ACTH及皮质醇的昼夜节律均无改变(p0.05)。结论:1、短期血浆FFAs水平升高对HPA轴基础分泌起抑制作用,
[Abstract]:Aim: to investigate the effects of free fatty acids on corticotropin, cortisol basal secretion and circadian rhythm in normal adults. Methods six healthy young male volunteers were randomly given 20% fat milk heparin (LHE group) and saline heparin (SH group) for 51 hours. The blood glucose, free fatty acid FFAsH, adrenocorticotropic hormone (ACTH) and cortisol were measured. The basal secretion and circadian rhythm of plasma ACTH and cortisol were compared between the two groups at different time points. Results there was no significant difference in blood glucose between the 8 am-11am-LHE group and SH group on the morning of the first day, but the second, The plasma FFAs level in the LHE group was significantly higher than that in the SH group 60 minutes after the trial, and was significantly higher than that in the SH group until the end of the trial. At the end of the trial, the plasma ACTH level in the first morning was significantly lower than that in the SH group, but on the second and third morning, the plasma ACTH level was significantly lower than that in the SH group. There was no significant difference between the two groups. On the morning of the first day, the plasma cortisol level in the 8am-11am-LHE group was significantly lower than that in the SH group (0.042%), but the circadian rhythm of plasma ACTH and cortisol in the two groups had no significant difference on the second and third morning (P 0.05), but there was no significant difference in the circadian rhythm of plasma ACTH and cortisol between the two groups. Conclusion the short-term increase of plasma FFAs level inhibits the basal secretion of HPA axis.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2006
【分类号】：R33

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