蛋白激酶Akt生物学功能的初步研究

发布时间：2018-03-13 17:49

本文选题：蛋白激酶Akt　切入点：RNA干涉　出处：《第四军医大学》2005年硕士论文　论文类型：学位论文

【摘要】：蛋白激酶Akt是一种蛋白质丝氨酸/苏氨酸激酶,因其与蛋白激酶A和蛋白激酶C具有相对高的同源性,亦被命名为蛋白激酶B(Protein kinase B,PKB)。它也是病毒癌基因的表达产物(v-Akt)在细胞内的同源类似物。蛋白激酶Akt在哺乳动物中存在三种亚型:Akt1,Akt2和Akt3。蛋白激酶Akt是一个多结构域蛋白,N端为PH结构域,中心为催化结构域,C端是一个与PKC调节区类似的区域。其中PH结构域可以和脂类第二信使PIP_3结合,使Akt向质膜转位而被活化,因此PH结构域对于Akt的活化发挥重要功能。蛋白激酶Akt作为磷脂酰肌醇-3激酶(PI3-kinase)的下游分子,它广泛参与细胞各种功能的调节。蛋白激酶Akt对代谢的影响主要表现为促进蛋白质的合成,促进糖原的转运。同时Akt作为一种介导细胞存活信号的重要分子,在细胞凋亡过程中的调节作用十分重要,其详细作用
[Abstract]:Protein kinase Akt is a serine / threonine protein kinase, and the protein kinase A and protein kinase C has relatively high homology, also called protein kinase B (Protein kinase B, PKB). It is also the expression of viral oncogenes (v-Akt) with source analogs in cells. There are three kinds of protein kinase Akt isoforms in mammals: Akt1, Akt2 and Akt3. protein kinase Akt is a multi domain protein N terminal PH domain, the center for the catalytic domain, C and PKC is a regulatory region of similar regions. The PH domain and the lipid second messenger PIP_3 the binding of Akt to plasma membrane translocation and activation of the PH domain play an important role in the activation of Akt protein kinase Akt as phosphatidylinositol -3 kinase (PI3-kinase) regulates downstream molecules, it is widely involved in cell functions. Effects of protein kinase Akt on the metabolism of the Lord To promote protein synthesis and promote glycogen transport, Akt plays an important role in regulating cell apoptosis and plays an important role in the process of cell apoptosis.

【学位授予单位】：第四军医大学
【学位级别】：硕士
【学位授予年份】：2005
【分类号】：Q55

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