体外人脑胶质瘤电阻抗特性及等效电路

发布时间：2018-03-19 05:28

本文选题：人脑胶质瘤　切入点：电阻抗　出处：《北京生物医学工程》2014年04期 　论文类型：期刊论文

【摘要】：目的研究人脑胶质瘤的电阻抗特性并建立其等效电路,可为进一步区分人脑胶质瘤和正常脑组织的阻抗特性差异提供依据。方法利用英国Solartron公司的阻抗分析仪(1260),采用四端法,在10Hz~10 MHz范围内,对4例体外人胶质瘤组织进行电阻抗测量。通过分析其频率特性并结合已有的人脑组织的等效电路,建立了体外胶质瘤的等效电路,利用阻抗分析软件Z-VIEW对其进行仿真。结果体外人脑胶质瘤的阻抗模值在10 Hz~10 MHz范围内随频率的增大而下降,相位角在该范围内随频率的增大而增大。体外人脑胶质瘤组织在10 kHz~10 MHz范围内电阻抗实部比较稳定,其中在10Hz~10 kHz范围内,实部随频率的增大而减小。电阻抗虚部在20 kHz~10 MHz范围内较稳定,而在10Hz~20 kHz范围内,虚部随频率增大而增大。样本的等效电路仿真曲线与实际曲线相比较,等效电路模型能较好地反映体外人脑胶质瘤的电阻抗特性。结论体外人脑胶质瘤与已知的正常脑组织的电阻抗特性及等效电路差别明显,这为探索生物电阻抗技术应用于区别胶质瘤与正常脑组织的临床应用提供了研究基础。
[Abstract]:Objective to study the electrical impedance characteristics of human glioma and establish its equivalent circuit, which can provide a basis for further differentiating the impedance characteristics between human glioma and normal brain tissue. The electrical impedance of 4 human glioma tissues in vitro was measured within 10 MHz. By analyzing its frequency characteristics and combining with the existing equivalent circuit of human brain tissue, the equivalent circuit of human glioma in vitro was established. The impedance analysis software Z-VIEW was used to simulate the glioma. Results the impedance modulus of human glioma in vitro decreased with the increase of frequency in the range of 10 Hz~10 MHz. In this range, the phase angle increases with the increase of frequency. In vitro, the electrical impedance of human glioma tissue is stable in the range of 10 kHz~10 MHz, and 10 kHz in the range of 10 Hz ~ 10 Hz. The real part decreases with the increase of frequency. The imaginary part of the impedance is stable in the range of 20 kHz~10 MHz, while the imaginary part increases with the increase of frequency in the range of 10 Hz ~ 20 kHz. The simulation curve of the equivalent circuit of the sample is compared with the actual curve. The equivalent circuit model can well reflect the electrical impedance characteristics of human gliomas in vitro. Conclusion the electrical impedance characteristics and equivalent circuits of human gliomas in vitro are obviously different from those of normal brain tissues. This provides a basis for the clinical application of bioelectrical impedance technique in differentiating gliomas from normal brain tissues.
【作者单位】：上海大学机电工程与自动化学院;第二军医大学第一附属医院神经外科;
【基金】：国家自然科学基金(81201988) 上海市科委基金(121409018021) 上海市学科带头人项目(10XD1401900) 上海市高校创新团队资助项目资助
【分类号】：R338

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