HCMV感染对血管内皮细胞ICAM-1表达的影响及药物干预的作用

发布时间：2018-03-25 06:02

本文选题：人巨细胞病毒　切入点：血管内皮细胞　出处：《河北医科大学》2005年硕士论文

【摘要】：目的:动脉粥样硬化(Atherosclerosis,AS)是严重危害人类健康和生命的动脉性疾病,但迄今其发病机制还不很清楚。近年来,逐渐认识到AS 是一种血管壁的慢性炎症,是内皮细胞对损伤因素的反应[1],因此,自1978 年Fabricant[2]用禽类疱疹病毒成功诱发火鸡冠状动脉粥样硬化以来,越来越多的研究显示作为其中一员的人巨细胞病毒(human cytomegalovirus,HCMV)感染与动脉粥样硬化有相关性。由于HCMV 在人群中感染非常广泛,可潜伏于多种细胞,当机体免疫低下时可重新激活造成严重感染,使HCMV 成为动脉性疾病发生的最可能的致病因素。大多数研究者认为,HCMV 的反复潜伏再激活可造成血管炎症反应,进而影响动脉性疾病的发生、发展以及稳定性[3]。其中主要的分子机制之一是由于HCMV 感染引起机体免疫损伤而加速疾病的进展。细胞间粘附因子-1(intercellular adhesion molecule-1, ICAM-1)是细胞表面的一种可被诱导的糖蛋白,可在造血祖细胞和非造血祖细胞表达,能介导免疫细胞与其他细胞间的相互作用,参与细胞粘附和移行,在炎症和免疫反应中起核心作用[4]。有研究发现[5],HCMV 感染可直接引起血管内皮细胞超微结构、代谢和功能等发生改变,但其对ICAM-1 动态表达的影响尚缺乏研究。膦甲酸钠( foscarnet sodium , PFA ) 和更昔洛韦
[Abstract]:Objective: Atherosclerotic Atherosclerotic Atherosclerotic Disease (ASA) is an arterial disease that seriously endangers human health and life, but its pathogenesis is not well understood. In recent years, it has been gradually recognized that as is a chronic inflammation of vascular wall. Is the response of endothelial cells to injury factors [1]. Therefore, since 1978 years after Fabricant successfully induced turkey coronary atherosclerosis with avian herpes virus, More and more studies have shown that human cytomegalovirus (HCMV) infection is associated with atherosclerosis. When the body is immunocompromised, it can reactivate and cause severe infection, which makes HCMV the most likely pathogenic factor of arterial diseases. Most researchers believe that repeated latent reactivation of HCMV can cause vascular inflammation, which in turn affects the occurrence of arterial diseases. Development and stability [3]. One of the main molecular mechanisms is to accelerate the progress of disease due to immune damage caused by HCMV infection. ICAM-1 is an inducible glycoprotein on the surface of cells, and ICAM-1 is an intercellular adhesion molecule-1. Can be expressed in hematopoietic progenitor cells and non-hematopoietic progenitor cells, can mediate the interaction between immune cells and other cells, participate in cell adhesion and migration, It has been found that [5] HCMV infection can directly cause changes in the ultrastructure, metabolism and function of vascular endothelial cells, but its effect on the dynamic expression of ICAM-1 has not been studied. Foscarnet sodium (PFA) and ganciclovir
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2005
【分类号】：R373

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