大鼠脑纹状体边缘区多巴胺受体及其与学习记忆功能的研究

发布时间：2018-03-27 09:48

本文选题：边缘区　切入点：纹状体　出处：《第一军医大学》2005年博士论文

【摘要】：脑纹状体边缘区(marginal division,MrD)是舒斯云等1987年在研究大鼠脑纹状体时发现的位于新纹状体尾内侧、环绕苍白球头外侧的一个由梭形细胞构成的新亚区,随后在猫、猴和人脑内也发现存在类似的结构,其富含多种神经肽类阳性纤维、终末和胞体,与脑内包括海马、杏仁核、Meynert氏基核和前额叶皮质等多个学习记忆相关脑区存在着结构和/或功能上的联系,是一个在细胞形态、神经递质和受体等生物大分子的分布,以及纤维联系方面均有别于纹状体其他部位的独特的亚区。该区富含SP、5-HT、DA、L-ENK、NT、SOM和TH等多种神经肽阳性纤维和胞体。该区和Meynert基底核及黑质等部位均有纤维联系。而且,己证实大鼠的MrD参与了电Y迷宫厌暗逃避条件反射联合型学习,在相同的行为模式训练后可观察到大鼠MrD细胞有c-fos、c-jun即早基因和与长期记忆形成密切相关的细胞核转录调节因子pCREB表达。最近,又进一步发现MrD涉及人的听觉数字工作记忆,临床上也观察到因MrD受损而出现认知功能障碍的患者。多巴胺(DA)是脑中丰富的儿茶酚胺类神经递质,广泛参与运动、认知、学习与记忆、情感、内分泌、正性强化等多种生理功能的调节。帕金森氏病、精神分裂症、抽动秽语综合征(Tourette's syndrome)、药物成瘾、高泌乳素血症等疾病都与多巴胺递质传递障碍有关。多巴胺发挥生理、病理等方面的作用是
[Abstract]:The marginal division of the striatum (Mr D) is a new subregion of fusiform cells found in the caudal part of the neo striatum, surrounding the lateral part of the globus pallidus, and then in cats, by Schusyun et al., in 1987, when he studied the striatum in rats. Similar structures have been found in monkeys and human brains, rich in a variety of neuropeptide positive fibers, terminals and cell bodies, and the brain, including the hippocampus, There are structural and / or functional connections in several learning and memory related brain areas, such as the Meynert's basal nucleus and the prefrontal cortex of the amygdala, which is a distribution of biological macromolecules such as cell morphology, neurotransmitters and receptors. This region is rich in many kinds of neuropeptide positive fibers and cell bodies, such as SPN5-HTTDAL-ENKSM-SOM and th. There are fiber connections between the region and the basal nucleus and substantia nigra of Meynert, and the relationship between the region and the basal nucleus of Meynert and substantia nigra is also found in this region, which is different from that in other parts of the striatum. It has been proved that the MrD of rats is involved in the combined learning of electrical Y maze, anaerobic and dark escape conditioned reflex. The expression of c-fos-c-jun, an early gene and nuclear transcription regulator pCREB, which is closely related to long-term memory formation, was observed in rat MrD cells after training in the same behavior pattern. Recently, it was further found that MrD is involved in human auditory digital working memory. Patients with cognitive impairment due to MrD impairment were also observed clinically. Dopamine (DA) is a rich catecholamine-like neurotransmitter in the brain, which is widely involved in the regulation of many physiological functions, such as motor, cognition, learning and memory, emotion, endocrine, positive reinforcement, etc. Tourette syndrome, drug addiction, hyperprolactinemia and other diseases are all related to dopamine transmitter transmission disorders. Dopamine plays a physiological and pathological role
【学位授予单位】：第一军医大学
【学位级别】：博士
【学位授予年份】：2005
【分类号】：R338

【参考文献】