延髓腹外侧头端微量注射三羟异黄酮对麻醉大鼠血压、心率和肾神经放电的影响

发布时间：2018-03-29 17:59

本文选题：三羟异黄酮　切入点：肾神经放电活动　出处：《河北医科大学》2006年硕士论文

【摘要】： 1926年首次报道植物提取物表现出雌激素性质。90年代,植物雌激素研究文献呈指数级增加。植物雌激素是一组天然植物化合物,其结构和生物活性均类似于雌激素,可与雌激素受体结合,具有弱雌激素样作用。植物雌激素存在于几乎所有种类的食物中,包括豆类、谷类、绿色蔬菜、水果和坚果。植物雌激素依据其分子结构的不同主要包括四类:(1)异黄酮类:主要有大豆甙元(7,4'-二羟异黄酮, DDZ),染料木黄酮(5,7,4'-三羟异黄酮, GST),芒柄花黄素,生物禅宁等;(2)木酚素类;(3)香豆素类;(4)真菌雌激素类。目前大多数实验以异黄酮类为研究对象,尤其对DDZ和GST最为深入。植物雌激素以无生物活性的形式存在于植物中,进入体内肠道可被水解为有活性的生物分子。异黄酮可最终转化为雌马酚和氧去甲基安哥拉紫檀素,这些代谢产物均与雌二醇相似。 GST在预防和治疗肿瘤、心血管疾病、骨质疏松和绝经后综合症等方面的作用已得到广泛认可,而且其在中枢神经系统的保护作用等方面研究也日益增多。GST能够在100 nM水平通过雌激素受体结合介导途径保护皮质神经元免受?淀粉样物质引起的损伤,可抑制大鼠大脑皮层神经元细胞中铁引起的脂质过氧化,增加去卵巢大鼠大脑皮层神经元蛋白质的合成,能够通过抑制酪氨酸蛋白激酶(PTK)途径恢复
[Abstract]:It was first reported in 1926 that the plant extract exhibited estrogen properties. In the 1990s, the phytoestrogen research literature increased exponentially. Phytoestrogen is a group of natural plant compounds, and its structure and biological activity are similar to that of estrogen. Phytoestrogens are present in almost all kinds of foods, including beans, cereals, green vegetables, Fruits and nuts. Phytoestrogens are mainly composed of four classes of isoflavones according to their molecular structure: daidzein, daidzein, daidzein, DDZN, genistein, GSTP, GSTP, Flavonoids, daidzein, daidzein, daidzein, daidzein, daidzein, daidzein, daidzein, and daidzein. At present, most experiments focus on isoflavones, especially for DDZ and GST. Phytoestrogens exist in plants in the form of bioactivity. The isoflavones can be transformed into estradiol and oxydemethylandrosin, which are similar to estradiol. The role of GST in the prevention and treatment of cancer, cardiovascular disease, osteoporosis and postmenopausal syndrome has been widely recognized. And its protective role in the central nervous system is also increasing. GST can protect cortical neurons from it through estrogen receptor binding mediated pathway at 100nM level. Amyloid damage can inhibit iron-induced lipid peroxidation in rat cerebral cortex neurons, increase protein synthesis of cerebral cortex neurons in ovariectomized rats, and recover by inhibiting tyrosine protein kinase (PTK) pathway.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2006
【分类号】：R33

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