令人烦恼的记忆

发布时间：2018-04-10 22:45

本文选题：记忆 + 遗忘　；参考：《生命科学》2014年06期

【摘要】：记载着挫折、恐惧、绝望等负性情绪的负性记忆,具有难以遗忘、令人烦恼的特点,与一些脑重大疾病,如创伤后应激综合征、抑郁症等存在密切关系。研究表明NMDA受体依赖性长时程增强在记忆的获取、储存等过程中起着关键作用。电休克和NMDA受体拮抗剂氯胺酮已知可导致短暂性遗忘,应用于治疗创伤后应激综合征、抑郁症具有起效快、疗效好的显著特点,提示这类脑疾病可能与负性记忆的遗忘特点有关。最近报道,遗忘具有独立的分子机理,在记忆和遗忘机理的共同作用下,既可能发生"记不住"如老年痴呆症、也可能出现"忘不了"如创伤后应激综合征和抑郁症等。深入研究遗忘的细胞分子机理,无疑有助于我们认识、预防和治疗相关脑重大疾病。
[Abstract]:Negative memories of negative emotions, such as frustration, fear and despair, are hard to forget and vexing, and are closely related to some major brain diseases, such as post-traumatic stress syndrome and depression.It has been shown that NMDA receptor-dependent long-term enhancement plays a key role in memory acquisition and storage.Electroshock and NMDA receptor antagonist ketamine are known to cause transient amnesia.The results suggest that these brain diseases may be related to the amnesia of negative memory.Recently, it has been reported that amnesia has an independent molecular mechanism. Under the joint action of memory and amnesia, it is possible to "forget", such as Alzheimer's disease, or "unforgettable", such as post-traumatic stress syndrome and depression.Further study of forgotten cellular and molecular mechanisms will undoubtedly help us to understand, prevent and treat major brain diseases.
【作者单位】：中国科学院昆明动物研究所学习记忆实验室中国科学院动物模型与人类疾病重点实验室;
【基金】：国家重点基础研究发展计划(“973”项目)(2013CB835100) CAS先导专项(XDB0202)
【分类号】：R338

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