无铝佐剂人用狂犬病疫苗（Vero细胞）免疫效果的研究

发布时间：2018-04-21 17:53

本文选题：疫苗 + 狂犬病毒　；参考：《吉林大学》2007年硕士论文

【摘要】： 狂犬病是由狂犬病毒引起的人兽共患疾病。人和所有温血动物对狂犬病毒都易感。该病在全世界广泛分布。由于该病一旦发病目前尚无法医治,动物传染源广泛存在,控制难度很大,所以对狂犬病及其预防制品的研究仍然是非常必要的。这对人类的健康和农牧业生产的发展具有重要的社会和经济意义。含AL(OH)3佐剂的狂犬病疫苗虽然有提高免疫力的作用,但由于作用缓慢,产生的中和抗体较迟,而狂犬病疫苗主要用于暴露后免疫,要求疫苗快速诱生中和抗体以发挥中和抑制病毒从而达到保护作用。根据国家对狂犬疫苗管理,要求用无铝佐剂的狂犬疫苗取代含铝佐剂的狂犬病疫苗。本文通过用无铝佐剂的狂犬病疫苗免疫动物,进行效力试验、淋巴细胞转化试验、中和抗体测定(快速狂犬病毒荧光抑制试验(RFFIT)法)。进一步观察无铝佐剂人用狂犬病疫苗的免疫效果。
[Abstract]:Rabies is a zoonotic disease caused by rabies virus. Humans and all warm-blooded animals are susceptible to rabies. The disease is widely distributed all over the world. Because the disease is still untreatable, the source of animal infection is widespread, and the control is very difficult, so the research on rabies and its prevention products is still very necessary. This is of great social and economic significance to human health and the development of agricultural and animal husbandry production. Rabies vaccine containing AL(OH)3 adjuvant can improve immunity, but because of its slow action, it produces late neutralizing antibody, and rabies vaccine is mainly used for post-exposure immunization. The vaccine is required to quickly induce neutralizing antibodies to neutralize the virus to protect it. According to the management of rabies vaccine, the rabies vaccine without aluminum adjuvant is required to replace the rabies vaccine containing aluminum adjuvant. By immunizing animals with aluminum-free rabies vaccine, the efficacy test, lymphocyte transformation test and neutralizing antibody assay (RFFITT) were carried out. To further observe the immune effect of human rabies vaccine without aluminum adjuvant.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2007
【分类号】：R392

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