基于文献数据库对中药免疫作用规律的探讨

发布时间：2018-04-26 09:00

本文选题：免疫 + 文献信息学　；参考：《大连医科大学》2006年硕士论文

【摘要】： 近年,中草药的现代化研究空前繁荣,中药作为中华民族的宝贵财富,在人类与疾病对抗中表现了自身的独特特点。中华传统药物,不仅在古代,而且在科技日益发达的今天,同样具有重要的地位。随着回归大自然思潮在世界范围内的出现和化学药物的毒副作用日益被人们所认识,中药以其确切的疗效和较低的毒副作用,越来越受到人们的青睐。免疫学在中药研究中占有重要地位,特别近年来,我国中药免疫学研究的工作取得很大的成绩,获得了大量科学数据及值得参考的文献资料,是中药研究的宝贵财富。但目前的研究大多局限于试验药理学的方法对中药进行药理研究,缺乏以中医理论为基础的系统的、规律性的研究。因此有必要从已有的信息资源中对不同功效、不同药性的药物的免疫作用进行分析,找出其中的规律性。本课题试图以已发表的有关中药免疫研究文献为研究基础,根据2005年版《中华人民共和国药典》,收集、筛选1980年以来的国内公开发表的有关中药植物药免疫研究的文献,并以实验验证文献信息选取的可靠性,利用可靠的文献信息探讨中医药免疫作用的规律性,开辟免疫药物筛选的新思路和新途径。本文提出了利用文献对有免疫调节作用的中药的认定原则(有两个或两个以上单位独立完成,并发表两篇以上的支持有免疫调节作用的论文),随机从药典中选择10种中药,文献检索表明有三种中药符合预先设计的有免疫调节作用的中药的认定原则。我们对三种中药(何首乌、山药、白芍)进行实验分析,以验证认定原则的可靠性。另取海参(亦符合预先设计的有免疫调节作用中药的认定原则)进行实验。以昆明小鼠为研究对象,取小鼠80只,分别注射卵清蛋白抗原进行免疫。将抗原免疫的小鼠分成五组,每个小组16只小鼠。其中第一组给予生理盐水灌胃,其余四组分别给予20%的何首乌、山药、白芍
[Abstract]:In recent years, the modernization research of Chinese herbal medicine has never been prosperous. As the precious wealth of the Chinese nation, Chinese medicine has shown its unique characteristics in the fight between human beings and diseases. Chinese traditional medicine, not only in ancient times, but also in the increasingly developed science and technology today, also has an important position. With the emergence of the trend of thought of returning to nature in the world and the toxic side effects of chemical drugs have been increasingly recognized, traditional Chinese medicine for its exact efficacy and lower side effects, more and more favored by people. Immunology plays an important role in traditional Chinese medicine research, especially in recent years, Chinese traditional medicine immunology research work has made great achievements, has obtained a large number of scientific data and reference documents, it is a valuable wealth of traditional Chinese medicine research. However, most of the current studies are limited to the pharmacological study of traditional Chinese medicine based on experimental pharmacology, and lack of systematic and regular research based on the theory of traditional Chinese medicine. Therefore, it is necessary to analyze the immunological effects of different efficacy and different drugs from the existing information resources to find out the regularity. Based on the published literatures on the immunology of traditional Chinese medicine (TCM), according to the 2005 edition of the Pharmacopoeia of the people's Republic of China, this paper attempts to collect and screen the published literatures on the immunity of traditional Chinese Medicines in China since 1980. The reliability of the selection of document information was verified by experiments, and the regularity of immune function of traditional Chinese medicine was discussed by using reliable literature information, which opened up a new idea and a new way of screening immunopharmaceuticals. In this paper, the principle of identifying traditional Chinese medicine with immunomodulatory effect by literature is put forward (two or more units are independent, and more than two papers supporting immunomodulation are published, 10 kinds of traditional Chinese medicine are selected randomly from pharmacopoeia, and 10 kinds of traditional Chinese medicine are selected from pharmacopoeia at random. Literature search showed that there were three kinds of traditional Chinese medicine in accordance with the pre-designed principles of immunomodulation of traditional Chinese medicine. Three kinds of traditional Chinese medicine (Polygonum multiflorum, Chinese yam, Radix Paeoniae Alba) were analyzed in order to verify the reliability of the principle. Sea cucumbers (also in accordance with the pre-designed principle of identification of traditional Chinese medicine with immunomodulatory effect) were also used to carry out the experiment. In this study, 80 Kunming mice were immunized with ovalbumin antigen. Mice immunized with antigens were divided into five groups, 16 mice in each group. The first group was given normal saline by stomach, and the other four groups were given 20% of Polygonum multiflorum, Chinese yam and Paeoniae Alba respectively.
【学位授予单位】：大连医科大学
【学位级别】：硕士
【学位授予年份】：2006
【分类号】：R28;R392

【参考文献】