我国铜绿假单胞菌耐氨基糖苷类基因分布的文献研究

发布时间：2018-05-08 07:59

  本文选题：铜绿假单胞菌 + 氨基糖苷类修饰酶　； 参考：《中国循证医学杂志》2014年07期

【摘要】：目的了解我国铜绿假单胞菌的氨基糖苷类耐药基因分布状况。方法计算机检索CBM、CNKI、VIP和WanFang Data数据库,收集报道我国铜绿假单胞菌耐氨基糖苷类基因的研究,检索时限均从建库至2012年12月。由2位评价员按照纳入与排除标准筛选文献、提取资料后,采用SPSS 17.0软件进行统计分析。结果共纳入10个省市1 144株耐氨基糖苷类铜绿假单胞菌。氨基糖苷类修饰酶基因aac(3’)-Ⅰ、aac(3’)-Ⅱ、aac(6’)-Ⅰ、aac(6’)-Ⅱ、ant(2’’)-Ⅰ、ant(3’’)-Ⅰ和aph(3’)-Ⅵ在淮河以北地区的检出率分别为13.3%、40.1%、21.6%、40.3%、38.1%、23.7%和2.9%,而淮河以南地区的检出率分别为3.2%、20.2%、15.9%、37.6%、28.3%、28.5%和9.1%。16S rRNA甲基化酶基因rmtA、rmtB和armA检出率分别为20.4%、19.4%和0.7%,而其余16S rRNA甲基化酶基因均未检出。结论氨基糖苷类修饰酶是我国铜绿假单胞菌耐氨基糖苷类药物的主要机制,而16S rRNA甲基化酶是其次要机制。
[Abstract]:Objective to investigate the distribution of aminoglycoside resistance genes of Pseudomonas aeruginosa in China. Methods the databases of VIP and WanFang Data were searched by computer, and the studies of aminoglycoside resistance genes of Pseudomonas aeruginosa in China were reported. The searching time was from the establishment of the library to December 2012. The literature was screened by two evaluators according to the inclusion and exclusion criteria, and the data were extracted and analyzed by SPSS 17.0 software. Results A total of 1 144 strains of aminoglycoside resistant Pseudomonas aeruginosa were included in 10 provinces and cities. The detection rates of the aminoglycoside modified enzyme gene aacanine (aacanine)-鈪，

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