建立犬主动脉夹层模型的初步研究

发布时间：2018-05-18 14:17

本文选题：夹层 + 动脉瘤　；参考：《第二军医大学》2005年硕士论文

【摘要】：研究目的:探索建立一种建立理想夹层模型的方法。研究不同时间点夹层标本的力学参数的变化,探索夹层的演变规律。方法:1.采用开胸的手术的方式,共尝试4种夹层复制方法,影像学检查观察夹层假腔的形态。2.多功能生物测试仪测量不同时间点夹层标本外壁和内壁的最大负荷和应变。结果:1.采用上述各方法均能复制出夹层模型,复制方法4最为理想。2.夹层内、外壁2W时的最大负荷小于1W时的最大负荷,随着时间的推移逐渐升高,1m时较1W、2W升高,而3m、6m、12m时变化不大。随夹层外壁标本的应变程度逐渐下降,夹层标本的弹性下降。结论:本实验复制方法4可以成功地建立较为符合病理生理的主动脉夹层模型。夹层标本内外壁的最大负荷呈现出如下趋势:2W时夹层的力学强度最低,随时间推移,夹层的力学强度逐渐增加,该趋势可能与组织的炎症反应与消退有关。随时间的推移,夹层外壁标本的应变程度逐渐下降,夹层壁弹性下降,硬度增加。该趋势可能与动脉壁组织的机化有关。
[Abstract]:Objective: to explore a method of establishing ideal interlayer model. The change of mechanical parameters of sandwich specimens at different time points was studied and the evolution law of interlayer was explored. Method 1: 1. Four kinds of mezzanine duplication methods were tried by open chest operation. The morphology of false cavity of mezzanine was observed by imaging examination. The maximum load and strain of the inner and outer walls of sandwich specimens at different time points were measured by a multifunctional biological tester. The result is 1: 1. The sandwich model can be duplicated by all the methods mentioned above, and method 4 is the most ideal. 2. 2. In the intercalation, the maximum load of the outer wall at 2W is less than that at 1W, and gradually increases with time at 1 m than that at 1W ~ 2W, but it does not change at 3m ~ 6m ~ (12) m. With the strain degree of the mezzanine wall decreased gradually, the elasticity of the sandwich specimen decreased. Conclusion: the model of aortic dissection which accords with pathophysiology can be successfully established by method 4 of this experiment. The maximum load of the inner and outer wall of the sandwich specimen showed the following trend: the mechanical strength of the interlayer was the lowest at the age of 2 W, and the mechanical strength of the interlayer increased gradually with the passage of time, which may be related to the inflammation reaction and the regression of the tissue. As time goes on, the strain degree of the sandwich wall decreases gradually, the elasticity of the sandwich wall decreases and the hardness increases. This trend may be related to the organization of arterial wall tissue.
【学位授予单位】：第二军医大学
【学位级别】：硕士
【学位授予年份】：2005
【分类号】：R-332

【参考文献】