环氧合酶在神经病理性痛中的作用及其机制研究

发布时间：2018-05-29 08:15

本文选题：环氧合酶 + 环氧合酶选择性抑制剂　；参考：《第四军医大学》2005年博士论文

【摘要】：疼痛一直是医学研究中的重要课题,除炎性疼痛外,神经病理性痛也是疼痛家族的一个重要成员。神经病理性痛是由神经系统的直接损伤、功能紊乱而引发的,其病理生理过程很复杂。神经病理性痛与其他疼痛的不同之处在于,即便造成损伤的因素已经消除,损伤已经消失,疼痛也依然会存在。因此,神经病理性痛通常都病程较长,给患者带来极大痛苦。神经病理性痛的治疗存在着很多棘手的问题,患者通常对阿片类药物反应不佳,而且由于成瘾性问题,不可能长期使用阿片类药物。由于神经元异常放电是神经病理性痛发病的机制之一,因此,一些能够抑制神经元异常放电,稳定细胞膜的药物,如抗抑郁药和抗惊厥药,也对神经病理性痛有治疗作用。但神经病理性痛是一个多因素作用的过程,除神经元异常放电外,神经元的可塑性改变等也与其相关。因此,单纯的细胞膜稳定剂还是不够的。近年来,研究发现一些前炎性因子,如TNFα,IL-6,IL-10等,都与神经病理性痛相关。环氧合酶(COX)是催化花生四烯酸转化为前列腺素过程中的关键酶,在炎性过程中起着重要作用。环氧合酶抑制剂在炎性痛的治疗中具有重要的治疗价值。环氧合酶已经研究的比较清楚的亚型有两种:COX-1和COX-2。近年来COX-3也已被分离鉴定。神经病理性痛后,脊髓的COX-1和COX-2水平可发生改变。但目前对环
[Abstract]:In addition to inflammatory pain, neuropathic pain is also an important member of pain family. Neuropathic pain is caused by direct injury and dysfunction of nervous system, and its pathophysiological process is very complicated. The difference between neuropathic pain and other pain is that even if the cause of the injury has been eliminated, the injury has disappeared, the pain will still exist. Therefore, neuropathic pain usually has a long course and brings great pain to patients. There are many thorny problems in the treatment of neuropathic pain. Patients usually have a poor response to opioid drugs, and because of addictive problems, it is impossible to use opioid drugs for a long time. As abnormal discharge of neurons is one of the mechanisms of neuropathic pain, some drugs that can inhibit abnormal discharges of neurons and stabilize cell membrane, such as antidepressants and anticonvulsants, also have therapeutic effects on neuropathic pain. But neuropathic pain is a multifactor process, and the plasticity of neurons is also related to the abnormal discharge of neurons. Therefore, the simple membrane stabilizer is not enough. In recent years, some proinflammatory factors, such as TNF 伪, IL-6, IL-10 and so on, have been found to be associated with neuropathic pain. Cyclooxygenase (COXX) is a key enzyme in the conversion of arachidonic acid to prostaglandin, which plays an important role in inflammatory process. Cyclooxygenase inhibitors play an important role in the treatment of inflammatory pain. There are two distinct subtypes of cyclooxygenase that have been studied: COX-1 and COX-2. In recent years, COX-3 has also been isolated and identified. After neuropathic pain, the levels of COX-1 and COX-2 in the spinal cord can be changed. But the current ring
【学位授予单位】：第四军医大学
【学位级别】：博士
【学位授予年份】：2005
【分类号】：R363

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