小鼠树突状细胞表面新型免疫抑制性受体DIgR2的功能研究

发布时间：2018-06-04 19:17

本文选题：树突状细胞 + 免疫球蛋白超家族　；参考：《浙江大学》2006年博士论文

【摘要】：树突状细胞(Dendritic cells,DCs)是体内功能最强的抗原递呈细胞(Antigen-presenting cells,APCs),在启动免疫应答和介导免疫耐受过程中起着关键作用。通过DCs表面活化性和抑制性受体传入胞内的各类信号,决定着DCs的状态和功能,以至影响着T细胞应答的强度和进度。在已知的表达于DCs的受体家族中,免疫球蛋白超家族(Ig-superfamily,IgSF)以其独特的结构特征,及在DCs发育和功能中的重要作用而独树一帜。IgSF成员多为I型膜蛋白分子,结构上以胞外段所具有的一个或几个免疫球蛋白样结构域为其主要特征,这些结构域对于细胞间的相互识别和作用至为关键。IgSF受体分子在免疫系统中数量众多,分布广泛,可表达于淋巴细胞和髓样细胞,包括T细胞、B细胞、DC、单核细胞及NK细胞等。众所周知,有相当数目的IgSF受体分子参与形成T细胞和抗原提呈细胞APCs之间的免疫突触(synapase),承担着抗原识别、细胞间相互作用以及信号传递等诸多重要任务。近来新发现的一些优先表达于DCs的Ig样受体分子,作为固有性和获得性免疫应答的重要调节者倍受人们关注。其中一部分Ig样分子作为抑制性受体(Inhibitory receptor)对免疫应答发挥重要调控作用。抑制性受体具有特征性的免疫受体酪氨酸相关抑制性基序(Immunoreceptor tyrosine-based inhibitory motifs,ITIM),当其与相应配体结合后,胞内ITIM基序可招募含有SH2结构域的蛋白酪氨酸磷酸酶,传递抑制性信号,以维持T细胞活化必要的阈值,避免无关细胞活化以及自身免疫的发生。尽管有不少表达于DCs的抑制性受体陆续被人们发现,但在目前对于DCs功能和机制尚未完全明了的情况下,进一步从DC中寻找新的免疫抑制性受体将有助于深
[Abstract]:Dendritic cells (DCs) are the most potent antigen-presenting cells in vivo and play a key role in initiating immune response and mediating immune tolerance. The state and function of DCs are determined by the signal of activation and inhibitory receptors on the surface of DCs, and the intensity and progress of T cell response are affected. The immunoglobulin superfamily Ig-superfamily IgSFs are unique in the receptor family known to be expressed in DCs because of their unique structural characteristics and important roles in the development and function of DCs. IgSF members are mostly type I membrane protein molecules. Structurally, one or more immunoglobulin-like domains of extracellular segments are the main features. These domains are crucial to the mutual recognition and interaction between cells. IgSF receptor molecules are numerous and widely distributed in the immune system. It can be expressed in lymphocytes and myeloid cells, including T cell B cells, monocytes and NK cells. It is well known that a considerable number of IgSF receptor molecules are involved in the formation of immunosynaptic synapases between T cells and antigen-presenting cells (APCs), which undertake many important tasks such as antigen recognition, intercellular interaction and signal transduction. Recently, some novel Ig-like receptor molecules preferentially expressed in DCs have attracted much attention as an important regulator of innate and acquired immune responses. Some Ig-like molecules play an important role in the regulation of immune response as inhibitory receptor. The inhibitory receptor tyrosine associated inhibitory motif tyrosine-based inhibitory motifs is a characteristic immunoreceptor inhibitory motif. When it binds to the corresponding ligand, the intracellular ITIM motif can recruit a protein tyrosine phosphatase containing the SH2 domain to transmit inhibitory signals. To maintain the necessary threshold for T cell activation to avoid unrelated cell activation and autoimmunity. Although a number of inhibitory receptors expressed in DCs have been discovered, further search for new immunosuppressive receptors from DC will be helpful when the function and mechanism of DCs are not fully understood at present.
【学位授予单位】：浙江大学
【学位级别】：博士
【学位授予年份】：2006
【分类号】：R392

【共引文献】