实验性动脉血压下降与体感皮层诱发电位及闪光视觉诱发电位的动态变化关系的探讨

发布时间：2018-06-11 20:43

本文选题：动脉血压 + 体感皮层诱发电位　；参考：《新疆医科大学》2005年硕士论文

【摘要】：目的:观察动脉血压下降过程中家兔大脑皮层诱发电位及闪光视觉诱发电位的动态变化,了解其与血压下降直至失血性休克过程之间的关系。探讨休克以及纠正休克后诱发电位变化的病理生理机制,为临床监测休克以及治疗提供实验依据。方法:1.记录放血前诱发电位,以及放血使血压每下降10mmHg(1.33kPa)时的皮层诱发电位和闪光视觉诱发电位,测量皮层诱发电位潜伏期、正波值、负波值的幅度,峰峰值幅度和时程以及闪光视觉诱发电位P_2波的潜伏时,P_2-N_2振幅,直到收缩压为40mmHg(5.32kPa)。对各组测量值进行前后和组间比较。2.记录放血前皮层诱发电位,然后放血至血压50～60mmHg(6.65～7.98kPa)记录皮层诱发电位,然后进行扩容治疗(补充所失血量及等量生理盐水和654-2 1mg/kg),半小时后血压恢复到80～100 mmHg(10.64～13.3kPa),测定皮层诱发电位的潜伏期、正波值、负波值的幅度及峰峰值的幅度和时程,进行组间比较。结果:(1)当血压由130mmHg降至90mmHg(17.29～11.97kPa)时,皮层诱发电位的正波、负波波幅随血压下降而降低,变化有统计学意义(P0.05)。血压在90～70mmHg(11.97～9.31kPa)变化时,正波值幅度变化无统计学意义(P0.05):血压在90～80mmHg(11.97～10.64kPa)与70～60mmHg(9.31～7.98kPa)时,负波值幅度变化无统计学意义(P0.05);血压在130～110mmHg(17.29～14.63kPa)时,峰峰值幅度变化无统计
[Abstract]:Aim: to observe the dynamic changes of cerebral cortex evoked potential (CBEP) and flash visual evoked potential (FVEP) in rabbits during the course of arterial blood pressure lowering (ABP) and to understand the relationship between them and the process of blood pressure decreasing to hemorrhagic shock. To explore the pathophysiological mechanism of shock and to correct the changes of evoked potential after shock, and to provide experimental basis for clinical monitoring of shock and treatment. Method 1: 1. The cortical evoked potential and flash visual evoked potential were recorded, and the latency, positive wave and negative wave amplitude of cortical evoked potential were measured. The amplitude and duration of peak and peak, and the latent time of P2 wave of flash visual evoked potential (SPVEP) were compared with the amplitude of P2-NAPL, until the systolic pressure was 40 mm Hgn 5.32 KPA. The measured values of each group were compared before and after and between groups. 2. The cortical evoked potentials were recorded, and then the blood pressure was 50 ~ 60mm HG 6.65 ~ 7.98kPa. the cortical evoked potentials were recorded, and the cortical evoked potentials (EPs) were recorded. Then the volume of blood loss and the same amount of normal saline and 654-21 mg / kg 路kg ~ (-1) were supplemented, and the blood pressure returned to 80 ~ 100 mm HgN 10.64 ~ (13. 3) KPA half an hour later. The latency, positive wave value, amplitude of peak and peak value and time course of cortical evoked potential were measured and compared between the two groups. Results (1) when blood pressure decreased from 130 mmHg to 90 mmHg, the positive wave and negative wave amplitude of cortical evoked potential decreased with the decrease of blood pressure (P 0.05). There was no significant difference in the amplitude of positive wave value between 90 and 70mm Hg (11.97 卤9.31 KPA). There was no statistical significance in the change of the amplitude of the positive wave value. There was no significant change in the amplitude of the negative wave at the time of the blood pressure of 90 ~ 80mm Hg (11.97 ~ 10.64kPa) and 70-60mmHg-1 (7.98kPa), but there was no statistical difference in the amplitude of the peak value at 130mm 110mm Hgn 17.2914.63kPa. at the same time, there was no statistical significance in the change of the amplitude of the negative wave.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2005
【分类号】：R363

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