日本血吸虫复合B细胞表位抗原的研究

发布时间：2018-06-11 22:05

本文选题：Biosun软件 + 预测　；参考：《江苏省血吸虫病防治研究所》2006年硕士论文

【摘要】： 血吸虫病是一种严重危害人类健康的人畜共患寄生虫病。我国是全球血吸虫病危害最严重的国家(埃及、苏丹、中国、巴西)之一,我国流行日本血吸虫病,主要流行于长江流域及以南的12个省(市、自治区)的434个县(市、区),受威胁的人口约2亿。经50多年防治血吸虫病的不懈努力,我国血吸虫病防治工作已取得了巨大的成绩。但目前全国仍有109个县(市、区)有血吸虫病流行,病人数达84.25万,病畜约2.41万头。血吸虫病的诊断在血吸虫病防治中起着极为重要的作用。随着血吸虫病防治措施的实施,流行区的感染度和感染率明显下降,以至血吸虫病经典的寄生虫学诊断方法-粪检的敏感性明显下降,并且由于粪便检查费工、费时、费力,疫区群众的依从性逐年下降,这种经典的寄生虫学诊断技术在现场大规模查病中的应用受到很大的限制。由于免疫诊断技术具有操作简便、敏感性较高、特异性较好等优点,因此发展免疫学诊断方法来代替或补充粪检为广大专业人员所采纳。常用的免疫学诊断方法所采用的检测抗原多为血吸虫成虫或虫卵抗原,这些抗原成分复杂且成本较高;而用基因工程方法制备完整的抗原虽可以获得较纯的抗原,但常常由于表达效率不高或纯化困难,因而限
[Abstract]:Schistosomiasis is a zoonotic parasitic disease that seriously endangers human health. China is one of the most serious countries (Egypt, Sudan, China, Brazil) in the world. Schistosomiasis japonicum is prevalent in China, mainly in 434 counties (cities) in 12 provinces (autonomous regions) south of the Yangtze River valley. The population at risk is about 200 million. After more than 50 years of unremitting efforts to control schistosomiasis, great achievements have been made in the prevention and control of schistosomiasis in China. But at present, there are 109 counties (cities and districts) with schistosomiasis epidemic in China, the number of people is 842500 and the number of animals is about 24100. The diagnosis of schistosomiasis plays an important role in the prevention and control of schistosomiasis. With the implementation of schistosomiasis control measures, the infection degree and infection rate in endemic areas decreased obviously, and the sensitivity of fecal examination, the classic parasitological diagnostic method of schistosomiasis, decreased obviously, and it was time-consuming and laborious because of the cost of stool examination. The compliance of the masses in epidemic areas is declining year by year. The application of this classical parasitological diagnosis technique in the field of large-scale disease detection is greatly limited. Because of the advantages of simple operation, high sensitivity, good specificity and so on, immunological diagnostic methods have been developed to replace or supplement fecal examination. Most of the commonly used immunological diagnostic antigens are the adult or egg antigens of Schistosoma japonicum, which are complicated and costly, but the relatively pure antigens can be obtained by using genetic engineering methods to prepare complete antigens. However, due to the low efficiency of expression or the difficulty of purification, it is often limited.
【学位授予单位】：江苏省血吸虫病防治研究所
【学位级别】：硕士
【学位授予年份】：2006
【分类号】：R392

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