微波热疗中辐射器形式和热场分布的研究

发布时间：2018-06-13 08:16

本文选题：微波热疗 + SAR　；参考：《第四军医大学》2005年博士论文

【摘要】：近年来,利用介入式微波或射频热疗技术治疗肿瘤已经在临床上得到了广泛应用。20世纪90年代前后,国内外都开展了化疗/放射+高温+药物的实验研究,发现加温可以诱发细胞凋亡,而且癌基因/抗癌基因与热敏性之间存在密切关系,在临床上使用这种方法治疗早期和中期的恶性肿瘤,也已取得了较好的预后效果。但是,由于对生物传热的基础研究不足,手术中加热时间、加热方式等问题没有得到很好解决,因而影响了疗效。要解决这些问题,就必须进一步研究热疗的热机理、加热过程中的物理变化和加热过程中组织内的场变化等,设计适当的辐射器和加热方式,进行建模研究,以准确预测热疗中组织热损伤区的程度和范围,用电磁场和热场的分布情况来为热疗提供理论依据。随着人体环境学的发展尤其是生物医学工程领域中低温外科手术、移植器官冷冻存储、肿瘤加热疗法、低温脑复苏康复措施、疾病热诊断技术、烧伤、冻伤、烫伤等临床医学和康复医学的进步,加之工程热物理学的横向发展,要求对人体生物传热现象的研究逐渐从定性研究过渡到定量研究,因此研究人体传热特性和传热机制就变得十分迫切了。
[Abstract]:In recent years, interventional microwave or radiofrequency thermotherapy has been widely used in clinical treatment of cancer. Around the 1990s, chemotherapeutic / radiothermic drug experiments have been carried out both at home and abroad. It was found that hyperthermia could induce apoptosis and there was a close relationship between oncogene / anticancer gene and thermosensitivity. However, due to the lack of basic research on biological heat transfer, the problems of heating time and heating mode in surgery are not well solved, thus affecting the curative effect. In order to solve these problems, it is necessary to further study the thermal mechanism of hyperthermia, physical changes in heating process and field changes in tissues during heating, and design appropriate radiators and heating methods for modeling. In order to accurately predict the extent and range of tissue thermal damage in hyperthermia, the distribution of electromagnetic and thermal fields is used to provide theoretical basis for hyperthermia. With the development of human environmental science, especially in the field of biomedical engineering, cryosurgery, cryopreservation of transplanted organs, tumor heating therapy, rehabilitation of hypothermia brain resuscitation, disease thermal diagnosis, burn, frostbite, The progress of clinical medicine and rehabilitation medicine such as scalding, coupled with the horizontal development of engineering thermophysics, requires the gradual transition from qualitative to quantitative research on the phenomenon of biological heat transfer in human body. Therefore, it is very urgent to study the heat transfer characteristics and heat transfer mechanism of human body.
【学位授予单位】：第四军医大学
【学位级别】：博士
【学位授予年份】：2005
【分类号】：R312

【相似文献】