乙酰肝素酶与相关疾病的研究进展

发布时间：2018-06-21 22:45

本文选题：乙酰肝素酶 + 硫酸肝素蛋白多糖　；参考：《中华妇幼临床医学杂志(电子版)》2014年04期

【摘要】：乙酰肝素酶(HPA)是人体内唯一能降解硫酸肝素蛋白多糖(HSPG)的一种β-D-葡萄糖醛酸内切酶。HSPG是细胞外基质(ECM)的重要组成部分,广泛分布于细胞表面,在正常组织的发育与病理学改变的发展中具有重要作用。HPA能识别HSPG的硫酸肝素链(HS)并将其降解,进而影响ECM与上皮细胞及内皮细胞基底膜结构,释放与HSPG结合的各种细胞因子。除通过降解HS产生间接生理作用外,HPA还以聚集、脱落、分裂素绑定的方式影响多配体聚糖的生物效应。另外,HPA可以增强信号级联效应,促进蛋白激酶的磷酸化和基因转录。因此,HPA的激活会引起一些病理生理学改变,包括炎性反应、血管形成、肿瘤转移、胚胎植入等。笔者拟就HPA与相关疾病的研究进展,进行综述如下。
[Abstract]:Heparanase (HPA) is the only 尾 -Dglucuronic acid endonuclease (HSPG) that can degrade heparin sulfate proteoglycan (HSPG) in human body. HSPG is an important component of extracellular matrix (ECM) and widely distributed on cell surface. HPA plays an important role in the development of normal tissues and pathological changes. HPA can recognize and degrade HSPG's heparin sulfate chain, and then affect ECM's basal membrane structure with epithelial cells and endothelial cells, and release various cytokines bound to HSPG. In addition to the indirect physiological effects of HS degradation, HPA also affects the biological effects of polyliganans by means of aggregation, shedding and kinin binding. In addition, HPA can enhance signal cascade effect, promote protein kinase phosphorylation and gene transcription. Therefore, the activation of HPA may cause some pathophysiological changes, including inflammatory response, angiogenesis, tumor metastasis, embryo implantation and so on. The research progress of HPA and related diseases is summarized as follows.
【作者单位】：四川大学华西第二医院麻醉科;四川大学华西第二医院妇产科;四川大学华西第二医院分子转化实验室;
【基金】：教育部博士点基金(20120181120046) 四川省科技应用基础项目(2014JY0081)~~
【分类号】：R346

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