植物性雌激素对子宫肌瘤模型大鼠血清NOS、TNF-α、IL-2水平及子宫平滑肌厚度的影响研究

发布时间：2018-06-23 19:23

本文选题：植物性雌激素 + 子宫肌瘤　；参考：《中国生化药物杂志》2014年09期

【摘要】：目的探究植物性雌激素对子宫肌瘤模型大鼠血清NOS、TNF-α、IL-2水平及子宫平滑肌厚度的影响。方法选取74只Wistar大鼠,采用腹腔注射苯甲酸雌二醇建立子宫肌瘤大鼠模型,随机分为2组。实验组36例,灌胃给予植物性雌激素依普黄酮溶液,对照组38例,灌胃给予非植物性雌激素结合雌激素溶液。治疗2周后,检测并比较2组大鼠血清NOS、TNF-α及IL-2水平。结果治疗后,对照组大鼠血清NOS、TNF-α水均较治疗前显著降低(P0.05),实验组大鼠血清NOS、TNF-α水平较治疗前显著升高(P0.05),治疗后实验组较对照组显著升高(P0.05)。治疗后,对照组大鼠IL-2水平较治疗前显著升高(P0.05);实验组大鼠IL-2水平较治疗前显著下降(P0.05)。治疗后,对照组大鼠子宫平滑肌厚度较治疗前显著减少(P0.05);实验组大鼠子宫平滑肌厚度较治疗前显著增加(P0.05);且实验组大鼠平滑肌厚度显著高于对照组(P0.05)。结论植物性雌激素可升高子宫肌瘤模型大鼠血清NOS、TNF-α含量、降低血清IL-2水平,对大鼠子宫平滑肌有显著的增厚作用,是加重子宫肌瘤模型大鼠病情的药物,不适用于子宫肌瘤患者的治疗,临床应对该药物的使用进行严格监管。
[Abstract]:Objective to investigate the effects of phytoestrogen on serum NOS- TNF- 伪 and uterine smooth muscle thickness in rats with uterine leiomyoma. Methods Seventy-four Wistar rats were randomly divided into two groups by intraperitoneal injection of estradiol benzoate to establish uterine leiomyoma model. The experimental group (n = 36) received phytoestrogenin solution by gavage, and the control group (n = 38) by non-phytoestrogen binding estrogen solution. After 2 weeks of treatment, the serum levels of NOS- TNF- 伪 and IL-2 were measured and compared between the two groups. Results after treatment, the serum NOSN TNF- 伪 level in the control group was significantly lower than that in the control group (P0.05), the serum NOSN TNF- 伪 level in the experimental group was significantly higher than that in the control group (P0.05), and that in the experimental group was significantly higher than that in the control group (P0.05). After treatment, the level of IL-2 in control group was significantly higher than that before treatment (P0.05), and the level of IL-2 in experimental group was significantly lower than that before treatment (P0.05). After treatment, the thickness of uterine smooth muscle in control group was significantly lower than that before treatment (P0.05); the thickness of uterine smooth muscle in experimental group was significantly higher than that before treatment (P0.05); and the thickness of smooth muscle in experimental group was significantly higher than that in control group (P0.05). Conclusion phytoestrogen can increase the content of serum NOSN TNF- 伪 and decrease the level of serum IL-2 in rats with uterine leiomyoma, and it can significantly increase the thickness of uterine smooth muscle in rats. It is a medicine for exacerbating the condition of uterine leiomyoma model rats. Not suitable for the treatment of hysteromyoma patients, clinical use of the drug should be strictly monitored.
【作者单位】：河北工程大学医学院护理系;南京市鼓楼医院妇产科;
【基金】：江苏省卫生厅项目(H200803)
【分类号】：R-332;R737.33

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