肠道病毒71型2A蛋白的研究进展

发布时间：2018-07-06 12:15

本文选题：肠道病毒 + A蛋白　；参考：《生命的化学》2014年06期

【摘要】：肠道病毒71(enterovirus 71,EV71)是手足口病(hand,foot and mouth disease,HFMD)主要致病原之一。手足口病临床上常表现为发热,手掌、脚掌及口腔黏膜皮疹或疱疹。然而,EV71感染导致的手足口病易伴随神经系统并发症,甚至死亡。EV71非结构蛋白2A作为蛋白酶和转录激活因子,在EV71生命周期中发挥重要作用。本文对2A的结构与功能研究进展进行综述,揭示2A的双重功能如何促进病毒复制和调控靶细胞,为进一步研究靶向2A的抗病毒疫苗和药物提供理论基础。
[Abstract]:Enterovirus 71 (enterovirus 71) is one of the major pathogens of hand-foot and mouth disease (HFMD). Hand-foot-mouth disease is often characterized by fever, rash or herpes in the palms, soles of feet and oral mucosa. However, HFMD caused by EV71 infection is prone to complications of nervous system, and even death. EV71 non-structural protein 2A, as a protease and transcription activator, plays an important role in EV71 life cycle. In this paper, the structure and function of 2A are reviewed, which reveals how the dual function of 2A promotes viral replication and regulates target cells, and provides a theoretical basis for the further study of antiviral vaccines and drugs targeting 2A.
【作者单位】：武汉大学基础医学院病原生物与感染性疾病研究所;过敏及免疫相关疾病湖北省重点实验室;
【基金】：国家自然科学基金项目(81171577) 中央高校基本科研业务费专项资金(201130102020001) 武汉大学医学部协同创新项目(266078)
【分类号】：R373

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