VGluT1在大鼠脊髓、背根神经节和外周神经末梢表达的形态学研究
发布时间：2018-08-19 09:02
【摘要】：谷氨酸作为哺乳类动物神经系统内重要的兴奋性递质,广泛分布于中枢和周围神经系统。在功能上,谷氨酸与神经元的发育、分化和突触传递密切相关。近年来,随着分子生物学技术的深入,人们已经成功地在脑内克隆出三种特异性的谷氨酸转运体(vesicular glutamate transporter,VGluTs)。由于它们都特异性的位于谷氨酸的囊泡膜上,在跨囊泡膜H~+浓度的改变和Cl~-参与的条件下,能协助谷氨酸向囊泡内转运。因此,这三种蛋白质分别被命名为囊泡膜谷氨酸转运体(VGluT1,VGluT2和VGluT3)。新近研究发现:VGluT1和VGluT2几乎特异性分布于所有中枢神经系统的谷氨酸能轴突终末内。因此,目前人们已将VGluT1和VGLuT2作为谷氨酸能轴突终末的标识物。在脊髓背角,VGluT1阳性终末主要分布于背角的Ⅱ层内侧部、Ⅲ层和Ⅳ～Ⅵ层的内侧部,而VGluT2阳性终末主要分布于背角的Ⅰ和Ⅱ层。VGluT3分布较为特殊,不仅分布于谷氨酸能神经终末,也存在于非谷氨酸能神经元的胞体、树突和轴突终末内。
[Abstract]:As an important excitatory transmitter in mammalian nervous system, glutamate is widely distributed in central and peripheral nervous system. In function, glutamate is closely related to the development, differentiation and synaptic transmission of neurons. In recent years, with the development of molecular biological techniques, three specific glutamate transporters (vesicular glutamate transporterus VGluts) have been successfully cloned in the brain. Because they are specifically located on the vesicular membrane of glutamate, they can assist in the transport of glutamate to the vesicle under the condition of transvesicular H- concentration change and Cl-participation. Therefore, these three proteins were named vesicular glutamate transporter (VGluT1, VGluT2 and VGluT3), respectively. A recent study found that the VGluT2 and VGluT1 were almost specifically distributed in all glutamate axons in the central nervous system (CNS). Therefore, VGluT1 and VGLuT2 have been used as markers of glutamate terminal. VGluT1 positive terminals in dorsal horn of spinal cord were mainly distributed in the medial part of layer 鈪，
本文编号：2191188
[Abstract]:As an important excitatory transmitter in mammalian nervous system, glutamate is widely distributed in central and peripheral nervous system. In function, glutamate is closely related to the development, differentiation and synaptic transmission of neurons. In recent years, with the development of molecular biological techniques, three specific glutamate transporters (vesicular glutamate transporterus VGluts) have been successfully cloned in the brain. Because they are specifically located on the vesicular membrane of glutamate, they can assist in the transport of glutamate to the vesicle under the condition of transvesicular H- concentration change and Cl-participation. Therefore, these three proteins were named vesicular glutamate transporter (VGluT1, VGluT2 and VGluT3), respectively. A recent study found that the VGluT2 and VGluT1 were almost specifically distributed in all glutamate axons in the central nervous system (CNS). Therefore, VGluT1 and VGLuT2 have been used as markers of glutamate terminal. VGluT1 positive terminals in dorsal horn of spinal cord were mainly distributed in the medial part of layer 鈪，
本文编号：2191188
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