耳鸣动物模型的建立及耳鸣大鼠听皮层可塑性的研究
发布时间：2018-08-27 16:09
【摘要】：一、背景与目的 耳鸣是在无外界相应声源刺激时耳内有响声的一种主观感觉，发病率极高。文献报告，持续性耳鸣患者约占总人口的10％，其中，大约有1％～3％的人群因耳鸣而严重影响正常工作和生活。可见，耳鸣引起的痛苦和烦恼有时比耳聋更大。因此，耳鸣受到越来越多的重视，已成为临床上迫切需要解决而又难以解决的顽症之一。由于缺少合适的动物模型，以往对耳鸣的研究多局限于人类，这大大限制了对耳鸣机制的深入了解。自从发现大剂量水杨酸钠类药物能引起人类耳鸣后，在动物体内注射大剂量的水杨酸钠就成为研究耳鸣机制的主要方法。由于无法判断注射水杨酸钠后动物是否真的感受到了耳鸣，最早期的研究只是建立在推测的基础上。1988年Jastreboff等按照巴甫洛夫条件反射原理，通过对大鼠行为学的观察，，证实了注射水杨酸钠后的大鼠确实感受到了耳鸣，并由此建立了现今广为应用的耳鸣动物行为学模型。这一模型的建立大大促进了对耳鸣机制的研究，但先前的研究多局限在水杨酸钠的外周耳毒性方面，近年来水杨酸钠的中枢效应逐渐引起了学者们的注意。研究表明水杨酸钠能引起动物听觉通路上神经元电活动的一系列改变，同时，在对耳鸣患者的研究中也发现了听皮层神经元代谢活动的增加和功能重组的证据。因此，听觉中枢特别是听皮层功能活动的变化可能在耳鸣的产生中具有更为重要的作用。已经证明，中枢神经系统功能活动的变
[Abstract]:Background & objective tinnitus is a kind of subjective sensation with high incidence when there is no external sound source. It is reported that persistent tinnitus patients account for about 10% of the total population, of which about 1% or 3% seriously affect normal work and life because of tinnitus. The pain and annoyance caused by tinnitus are sometimes greater than deafness. Therefore, tinnitus has been paid more and more attention. Due to the lack of suitable animal models, previous studies on tinnitus were limited to humans, which greatly limited the understanding of tinnitus mechanism. Since it was found that large doses of sodium salicylate can cause tinnitus in humans, the injection of sodium salicylate into animals has become the main method to study the mechanism of tinnitus. Since it was impossible to determine whether the animals actually felt tinnitus after injection of sodium salicylate, the earliest studies were based on speculation. In 1988, Jastreboff et al observed the behavior of rats according to Pavlov's conditioned reflex principle. It was confirmed that the rats after injection of sodium salicylate did feel tinnitus, and the animal behavioral model of tinnitus was established. The establishment of this model has greatly promoted the study of tinnitus mechanism, but previous studies are mostly confined to the peripheral ototoxicity of sodium salicylate. In recent years, the central effect of sodium salicylate has gradually attracted the attention of scholars. It has been shown that sodium salicylate can induce a series of changes in the electrical activity of neurons in the auditory pathway of animals. At the same time, evidence of increased metabolic activity and functional recombination of neurons in auditory cortex has also been found in the study of tinnitus patients. Therefore, the changes of auditory center, especially auditory cortex, may play a more important role in tinnitus production. It has been shown that central nervous system function changes
【学位授予单位】：郑州大学
【学位级别】：硕士
【学位授予年份】：2006
【分类号】：R-332;R764.45
本文编号：2207774
[Abstract]:Background & objective tinnitus is a kind of subjective sensation with high incidence when there is no external sound source. It is reported that persistent tinnitus patients account for about 10% of the total population, of which about 1% or 3% seriously affect normal work and life because of tinnitus. The pain and annoyance caused by tinnitus are sometimes greater than deafness. Therefore, tinnitus has been paid more and more attention. Due to the lack of suitable animal models, previous studies on tinnitus were limited to humans, which greatly limited the understanding of tinnitus mechanism. Since it was found that large doses of sodium salicylate can cause tinnitus in humans, the injection of sodium salicylate into animals has become the main method to study the mechanism of tinnitus. Since it was impossible to determine whether the animals actually felt tinnitus after injection of sodium salicylate, the earliest studies were based on speculation. In 1988, Jastreboff et al observed the behavior of rats according to Pavlov's conditioned reflex principle. It was confirmed that the rats after injection of sodium salicylate did feel tinnitus, and the animal behavioral model of tinnitus was established. The establishment of this model has greatly promoted the study of tinnitus mechanism, but previous studies are mostly confined to the peripheral ototoxicity of sodium salicylate. In recent years, the central effect of sodium salicylate has gradually attracted the attention of scholars. It has been shown that sodium salicylate can induce a series of changes in the electrical activity of neurons in the auditory pathway of animals. At the same time, evidence of increased metabolic activity and functional recombination of neurons in auditory cortex has also been found in the study of tinnitus patients. Therefore, the changes of auditory center, especially auditory cortex, may play a more important role in tinnitus production. It has been shown that central nervous system function changes
【学位授予单位】：郑州大学
【学位级别】：硕士
【学位授予年份】：2006
【分类号】：R-332;R764.45
【参考文献】
相关期刊论文 前2条
1 李明,杨光,关颖,马兆鑫;耳鸣动物行为学模型的制作[J];中国中西医结合耳鼻咽喉科杂志;2003年03期
2 刘俊秀,李学佩,董钰,韩慧婉,刘国诠;利用微透析技术对利多卡因治疗耳鸣作用机制的实验研究[J];中华耳鼻咽喉科杂志;2003年06期
本文编号：2207774
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