下颌神经切断术后VGluT1和CGRP在大鼠三叉神经复合体中表达的变化

发布时间：2018-09-12 05:45

【摘要】：周围神经作为联系中枢神经系统(central nervous system，CNS)与外周感受器或者效应器之间的桥梁，在神经传递、神经营养等方面发挥着重要作用。由于其分布广泛的特点，常因外伤、压迫及缺血而损伤。以往的研究表明，周围神经损伤能够引起受损神经元(包括初级传入神经元和运动神经元)的胞体或终末内某些神经活性物质及其受体的表达发生一系列变化，其中与神经生长和营养有关的物质常发生上调，而与神经传递有关的物质则发生下调；与此同时，受损神经元的周围常伴随发生胶质反应及神经胶质增生等变化。所有这些变化被认为是神经元对其所受损伤的一种适应性反应。谷氨酸(glutamate，Glu)是初级传入纤维内重要的神经递质，，Glu在神经元内合成后必须被囊泡膜谷氨酸转运体(vesicular glutamate transporter，VGluT)转运到突触囊泡内，才能通过胞吐作用完成突触传递。目前人们已经发现了三种VGluTs，即VGluT1、VGluT2和VGluT3，并认为它们能够作为Glu能神经纤维终末的特异性标记物。最近的研究显示，传递触压觉和本体觉信息的初级传入纤维主要表达VGluT1，而传递伤害性信息的初级传入纤维主要表达VGluT2，但在初级传入纤维中未见
[Abstract]:Peripheral nerves, as a bridge between the central nervous system (CNS) and peripheral receptors or effectors, play an important role in nerve transmission, neurotrophic and other aspects. The expression of some neuroactive substances and their receptors in the soma or terminals of damaged neurons (including primary afferent neurons and motor neurons) has undergone a series of changes, in which substances related to nerve growth and nutrition are often up-regulated, while substances related to nerve transmission are down-regulated; at the same time, the periphery of damaged neurons is down-regulated. All these changes are thought to be an adaptive response of neurons to the damage they cause.
Glutamate (Glu) is an important neurotransmitter in primary afferent fibers. Glu synthesized in neurons must be transported to synaptic vesicles by vesicular glutamate transporter (VGluT) to complete synaptic transmission through exocytosis. VGluT3 is considered to be a specific marker of Gluergic nerve fiber terminals. Recent studies have shown that primary afferent fibers that transmit tactile and proprioceptive information mainly express VGluT1, while primary afferent fibers that transmit noxious information mainly express VGluT2, but not in primary afferent fibers.
【学位授予单位】：第四军医大学
【学位级别】：硕士
【学位授予年份】：2006
【分类号】：R363

【参考文献】