结核分枝杆菌PPE家族免疫相关蛋白PPE68免疫功能的研究

发布时间：2018-10-17 11:30

【摘要】：结核病是由结核分枝杆菌所引发的一种传染病,近年来,随着人口流动增加、多重耐药菌株的出现以及结核分枝杆菌与人类免疫缺陷病毒(HIV)的联合感染,结核病对人类的健康形成日益严重的威胁。卡介苗作为预防结核病的唯一疫苗,其保护效力却极不稳定,因此越来越多的研究者致力于结核分枝杆菌疫苗的研制和开发领域,如毒力基因的研究、疫苗候选基因的筛选及其编码产物免疫原性与免疫保护性的研究、以及对卡介苗的改造等。结核分枝杆菌是一种胞内致病菌,可以通过多种机制逃避机体免疫细胞的杀伤及清除,从而在其宿主细胞——巨噬细胞中进行自我复制和繁殖,并长期存活于机体内。当机体免疫能力下降时,潜伏的结核杆菌就会大量繁殖而导致结核病的发生。现已证明,RD1区基因编码的蛋白质是结核分枝杆菌的主要毒力因子,在结核杆菌疫苗研制开发和检测诊断方面都受到了广泛的重视。PPE68蛋白由RD1区的Rv3873基因所编码,是RD1区免疫原性的重要组成部分之一,可以在结核感染病人体内诱发强烈的T淋巴细胞反应。另外,PPE68做为PPE蛋白家族的成员,其特殊的
[Abstract]:Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. In recent years, with the increase of population flow, the emergence of multidrug resistant strains and the co-infection of Mycobacterium tuberculosis and human immunodeficiency virus (HIV). Tuberculosis poses an increasingly serious threat to human health. BCG vaccine is the only vaccine to prevent tuberculosis, but its protective effect is very unstable. Therefore, more and more researchers are devoting themselves to the research and development of Mycobacterium tuberculosis vaccine, such as virulence gene. Screening of vaccine candidate genes, immunogenicity and immunogenicity of encoding products, and modification of BCG vaccine. Mycobacterium tuberculosis is a kind of intracellular pathogenic bacteria, which can escape the killing and clearing of immune cells through many mechanisms, and then replicate and reproduce in its host cells, macrophages, and survive in the organism for a long time. When the body's immune capacity decreases, the latent Mycobacterium tuberculosis will proliferate in large numbers, leading to the occurrence of tuberculosis. It has been proved that the protein encoded by RD1 region gene is the main virulence factor of Mycobacterium tuberculosis, and has been widely paid attention to in the research and development of TB vaccine and detection and diagnosis. PPE68 protein is encoded by Rv3873 gene in RD1 region. It is one of the important components of immunogenicity in RD1 region, which can induce strong T lymphocyte reaction in TB infected human body. In addition, PPE68 is a member of the PPE family.
【学位授予单位】：四川大学
【学位级别】：硕士
【学位授予年份】：2005
【分类号】：R392

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