小鼠卵巢囊淋巴孔的发现及吸收功能的研究

发布时间：2018-10-29 19:00

【摘要】：淋巴孔是毛细淋巴管在间皮面的微小开口,是恒定的结构。1863年vonRecklinghausen首先报道腹膜淋巴孔。1977年Tsilibary等在电子显微镜下证实小鼠腹膜淋巴孔的存在。1991年李继承等报道了人膈腹膜淋巴孔,并对其功能进行了研究,认为它具有可调控性,并参与局部免疫、肿瘤转移、腹水形成和腹膜透析失超滤等生理病理过程。此后,人们相继在人肝镰状韧带、人盆腹膜、蛙心包膜及家兔肋胸膜等部位发现淋巴孔。同时生殖系统淋巴孔的研究也引起学者的关注,卵巢系膜(mesotubarium superius,MTS)是联系卵巢和阔韧带的腹膜,其发育程度有很大的种属差异。如灵长类动物的卵巢系膜几乎缺如,卵巢广泛暴露在腹膜腔;而大多数啮齿类动物的卵巢系膜高度发展形成一个完全闭合或半闭合、包裹卵巢的囊,这个囊称卵巢囊(ovary bursa)。卵巢囊和卵巢之间存在一个含液体的腔隙,称为卵巢囊腔(bursal cavity)。1985年Shinohara等首先描述了金仓鼠卵巢囊内壁上皮有淋巴孔,并提出这些淋巴孔可能有物质转运及影响卵巢发育和生殖的功能。此后,又陆续发现了欧洲海狸的卵巢囊上皮淋巴孔,鸡、鹑胚胎的卵巢上皮淋巴孔。2001年隋梅花、李继承首次报道了豚鼠卵巢囊淋巴孔和人卵巢上皮淋巴孔的存在,并认为淋巴孔与卵巢内淋巴管和腹膜腔间的物质转运、局部免疫有关,甚至可能影响生殖功能。由于小鼠足最常见的实验用啮齿类
[Abstract]:The lymphatic foramen is the tiny opening of the lymphatic capillary in the mesothelium. In 1863, vonRecklinghausen first reported peritoneal lymphatic foramen. Tsilibary et al confirmed the existence of peritoneal lymphatic foramen in mice under electron microscope in 1977. In 1991, Li inherited et al reported the human phrenic peritoneal lymphatic foramen and its function. It is considered that it is controllable and involved in local immunity, tumor metastasis, ascites formation and peritoneal dialysis ultrafiltration. After that, lymphatic foramen was found in human falciform ligament, human pelvic peritoneum, frog pericardium and rabbit's costal pleura. At the same time, the study of lymphatic foramen of reproductive system has also attracted the attention of scholars. The ovarian mesangium (mesotubarium superius,MTS) is the peritoneum that connects the ovary and the broad ligament, its development degree has the very big species difference. For example, the ovarian mesangium of primates is almost absent and the ovary is widely exposed to the peritoneal cavity; whereas the ovarian mesangium of most rodents develops into a completely closed or semi-closed ovarian capsule, which is called the ovarian sac (ovary bursa). There is a liquid lacuna between the ovary sac and ovary. (bursal cavity). 1985 Shinohara et al. First described the lymphatic foramen in the inner wall of ovarian cyst of golden hamster. It is suggested that these lymphatic foramen may have the function of material transport and affecting ovarian development and reproduction. Since then, European beaver ovarian cystic lymphoid foramen and ovarian epithelial lymphoid foramen of chicken and quail embryos have been discovered one after another. In 2001, Li Sui-hua first reported the existence of ovarian cystic lymphoid foramen and human ovarian epithelial lymphoid foramen in guinea pigs. It is suggested that the lymphatic foramen is related to the transport of substance between the lymphatic vessels and the peritoneal cavity of the ovary and local immunity, and may even affect the reproductive function. Due to the most common laboratory rodents of mouse feet
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2005
【分类号】：R339.2

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