腺苷及其受体对中性粒细胞在炎症中的作用与机制研究进展

发布时间：2018-10-30 07:36

【摘要】：腺苷,作为机体内ATP代谢过程中的重要产物,通过激活腺苷受体(adenosine receptors,AR)(A1R、A2AR、A2BR、A3R)参与了机体的许多生理及病理过程的调节。腺苷受体在体内的各个组织器官具有广泛的分布,在免疫系统尤为丰富,如中性粒细胞、巨噬细胞、淋巴细胞、树突状细胞均有较高表达。炎症,是机体抵御外来刺激的一种防御性免疫机制,过度的炎症反应则会对机体造成损伤,中性粒细胞是其中重要的参与者之一,腺苷及其受体的调节密切参与了其黏附、迁移、细菌杀伤作用、炎症介质产生、凋亡等过程,从而对炎症起到调节作用。
[Abstract]:Adenosine, as an important product of ATP metabolism, is involved in many physiological and pathological processes by activating adenosine receptor (adenosine receptors,AR). Adenosine receptors are widely distributed in various tissues and organs, especially in the immune system, such as neutrophils, macrophages, lymphocytes and dendritic cells. Inflammation is a defensive immune mechanism in which the body resists foreign stimuli. Excessive inflammatory reactions can damage the body. Neutrophils are one of the important participants, and the regulation of adenosine and its receptors is closely involved in its adhesion. Migration, killing of bacteria, production of inflammatory mediators, apoptosis and other processes, which play a role in the regulation of inflammation.
【作者单位】：第三军医大学基础部生物化学与分子生物学教研室;
【基金】：国家自然科学基金(31370913,81322044) 第三军医大学校级科研课题(2012XJQ01)
【分类号】：R363

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