结核分枝杆菌Rpf样蛋白生物学及免疫学活性的研究
发布时间：2018-10-30 09:14
【摘要】：结核病(Tuberculosis,TB)是由结核分枝杆菌(Mycobacterium tuberculosis,MTB)引起的以呼吸道传播为主的慢性传染性疾病。近年来,由于卡介苗(BCG)保护性的不完善、MTB耐药性的产生、艾滋病的流行、世界人口的剧增、全球性旅游业的发展以及吸毒、酗酒、贫穷等原因,TB的发病率呈日益严重的回升趋势,再次成为危害人类健康的世界性疾病。WHO指出,全世界现有TB患者2000万,每年新发生约900万例,每年死亡约300万例。WHO预测,在未来的10年中,全球将有超过3亿人感染MTB,9000万人发病,3000万人死于TB。因此,积极研究TB的致病及免疫机制,研制更为有效的诊断、预防和治疗MTB感染的新技术、新方法、新疫苗等具有重要意义。 藤黄微球菌(Micrococcus luteus)中的促进复活因子(resuscitation-promoting factor,Rpf)是被发现的第一种细菌的细胞因子,它具有促进休眠菌的复苏以及促进细菌快速生长的作用。序列对比分析发现,在其他的一些革兰阳性细菌如MTB、麻风分枝杆菌、蓝色链霉菌、谷氨酸棒杆菌等中也存在着30多个与Rpf同源的蛋白,其中在MTB中就有5个Rpf样蛋白,分别为Rv1884c、Rv2389c、Rv2450、Rv1009和Rv0867,推测这些蛋白也可能具有促进MTB快速生长的作用。此外,
[Abstract]:Tuberculosis (Tuberculosis,TB) is a chronic infectious disease mainly caused by mycobacterium tuberculosis (Mycobacterium tuberculosis,MTB). In recent years, due to the imperfect protection of BCG (BCG), the emergence of drug resistance to MTB, the prevalence of AIDS, the rapid growth of the world population, the development of global tourism, and the causes of drug abuse, alcohol abuse, poverty, and so on, The incidence of TB is on the rise and is once again a worldwide disease that endangers human health. WHO points out that there are 20 million TB patients in the world, about 9 million new cases annually, and about 3 million deaths per year. WHO predicts that, In the next 10 years, more than 300 million people worldwide will be infected with MTB, and 30 million will die of TB. Therefore, it is of great significance to study the pathogenesis and immune mechanism of TB, to develop a more effective diagnosis, prevention and treatment of MTB infection of new technology, new methods, new vaccines and so on. Resuscitation-promoting factor,Rpf is the first bacterial cytokine found in (Micrococcus luteus) of Micrococcus luteus. It can promote the recovery of dormancy bacteria and the rapid growth of bacteria. Sequence analysis showed that there were more than 30 Rpf homologous proteins in other Gram-positive bacteria such as Mycobacterium MTB, Streptomyces blue and Corynebacterium glutamate, among which 5 Rpf like proteins were found in MTB. Rv1884c,Rv2389c,Rv2450,Rv1009 and Rv0867, suggest that these proteins may also promote the rapid growth of MTB. In addition,
【学位授予单位】：第四军医大学
【学位级别】：博士
【学位授予年份】：2005
【分类号】：R392
本文编号：2299579
[Abstract]:Tuberculosis (Tuberculosis,TB) is a chronic infectious disease mainly caused by mycobacterium tuberculosis (Mycobacterium tuberculosis,MTB). In recent years, due to the imperfect protection of BCG (BCG), the emergence of drug resistance to MTB, the prevalence of AIDS, the rapid growth of the world population, the development of global tourism, and the causes of drug abuse, alcohol abuse, poverty, and so on, The incidence of TB is on the rise and is once again a worldwide disease that endangers human health. WHO points out that there are 20 million TB patients in the world, about 9 million new cases annually, and about 3 million deaths per year. WHO predicts that, In the next 10 years, more than 300 million people worldwide will be infected with MTB, and 30 million will die of TB. Therefore, it is of great significance to study the pathogenesis and immune mechanism of TB, to develop a more effective diagnosis, prevention and treatment of MTB infection of new technology, new methods, new vaccines and so on. Resuscitation-promoting factor,Rpf is the first bacterial cytokine found in (Micrococcus luteus) of Micrococcus luteus. It can promote the recovery of dormancy bacteria and the rapid growth of bacteria. Sequence analysis showed that there were more than 30 Rpf homologous proteins in other Gram-positive bacteria such as Mycobacterium MTB, Streptomyces blue and Corynebacterium glutamate, among which 5 Rpf like proteins were found in MTB. Rv1884c,Rv2389c,Rv2450,Rv1009 and Rv0867, suggest that these proteins may also promote the rapid growth of MTB. In addition,
【学位授予单位】：第四军医大学
【学位级别】：博士
【学位授予年份】：2005
【分类号】：R392
【引证文献】
相关博士学位论文 前1条
1 樊爱琳;Rpf蛋白结构域的生物学及免疫学特性的初步研究[D];第四军医大学;2008年
，本文编号：2299579
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