229对生殖异常夫妇染色体多态性分析

发布时间：2018-11-05 17:44

【摘要】：目的:以生殖异常患者染色体多态性的检出率为主因素进行研究,探讨染色体多态性与生殖异常之间的关系。方法:从2004年1月~2006年1月就诊于吉大一院检验科及基础医学院生殖医学化验室进行细胞遗传学检查的患者中筛选229对生殖异常夫妇(包括妊娠胎儿丢失、不孕不育及有缺陷儿出生)作G显带染色体核型分析。结果:1. 229对生殖异常夫妇中染色体多态性变异检出率为10.7%,明显高于普通人群中的发生率(P0.05);男女比例为8.8:1,相差悬殊。2. 1、9、16号染色体次缢痕增加检出率为1.5%,inv(9)检出率为0.4%,大Y检出率为7.6%,D/G组染色体短臂延长检出率为1.1%。3.妊娠胎儿丢失、不孕不育、有缺陷儿出生等生殖异常患者染色体多态性变异检出率均明显高于普通人群中的发生率(P0.05)。4.胎儿丢失发生于妊娠早期者染色体多态性变异检出率高于胎儿丢失发生于妊娠中、晚期者的检出率(P0.05),而后两者的检出率之间无统计学差异(P0.05)。5.异常孕产≥3次者染色体多态性变异检出率均高于异常孕产1次和2次者的检出率(P0.05),而后两者的检出率之间无统计学差异(P0.05)。结论:染色体多态性与生殖异常具有相关性,且大多影响胚胎发育的早期阶段,随着异常孕产次数增加,夫妇一方染色体多态性变异比率有相应增高的趋势。
[Abstract]:Objective: to investigate the relationship between chromosome polymorphism and reproductive abnormality. Methods: from January 2004 to January 2006, 229 couples with abnormal reproduction (including the loss of pregnancy fetus) were selected from the laboratory of reproductive medicine and the laboratory of reproductive medicine of the first Hospital of Jida for cytogenetic examination. The karyotype of G-banded chromosomes was analyzed. The result is 1: 1. The detection rate of chromosome polymorphisms in 229 couples with abnormal reproduction was 10.7, which was significantly higher than that in the general population (P0.05), and the ratio of male to female was 8.88: 1, the difference was significant. 2. The increase rate of chromosome 1, chromosome 9 and chromosome 16 was 1.5%. The detection rate of small Y was 0.4 and the detection rate of large Y was 7.6%. The detection rate of short arm lengthening was 1.1% and 1.3% respectively. The detection rate of chromosomal polymorphisms in pregnant women with fetal loss, infertility and birth defects was significantly higher than that in the general population (P0.05). The detection rate of chromosomal polymorphisms in early pregnancy was higher than that in late pregnancy (P0.05), but there was no significant difference between the latter two (P0.05). The detection rate of chromosome polymorphism in abnormal pregnancy 鈮，

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