LncRNA的结构研究及进展
发布时间：2018-11-09 07:50
【摘要】：正近年发现的长链非编码RNA(long non-coding RNA,lncRNA)在细胞生长、发育、表观遗传学以及肿瘤和心血管疾病发生过程中,发挥重要的调控作用[1-9]。LncRNAs长度为1 000～10 000个碱基,通常是多聚腺苷酸化的,受RNA聚合酶Ⅱ催化转录合成[3,6,7]。LncRNAs主要分布于胞核,在胞浆中也有存在。很多lncRNAs与组蛋白修饰、染色质重塑和表观遗传效应有关[10]。但是,表观遗传因子识别它们的作用机制仍然是个谜。在哺乳动物的基因组中,lncRNAs的重要性已引起研究者的重视,lncRNAs可能在
[Abstract]:Long chain noncoding RNA (long non-coding RNA,lncRNA (RNA (long non-coding RNA,lncRNA) has been discovered in recent years in cell growth, development, epigenetics, tumorigenesis and cardiovascular disease. [1-9] .The length of LncRNAs is 1 000 ~ 10 000 bases, usually polyadenosylated, and transcriptional synthesis is catalyzed by RNA polymerase 鈪，
本文编号：2319800
[Abstract]:Long chain noncoding RNA (long non-coding RNA,lncRNA (RNA (long non-coding RNA,lncRNA) has been discovered in recent years in cell growth, development, epigenetics, tumorigenesis and cardiovascular disease. [1-9] .The length of LncRNAs is 1 000 ~ 10 000 bases, usually polyadenosylated, and transcriptional synthesis is catalyzed by RNA polymerase 鈪，
本文编号：2319800
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