符合生理过程的松质骨骨质疏松计算模型研究及应用

发布时间：2018-11-26 10:05

【摘要】：建立在一定实验基础上的计算机定量数值模拟是目前国内外研究的热点问题。本论文的研究工作即是在国内外实验研究成果基础上,建立新的带有时间历程的力学-生物学因素耦联的松质骨骨质疏松过程定量计算模型,探讨它在模拟废用型骨质疏松,和妇女绝经期因受力水平降低,雌激素水平下降引起的骨质疏松中的应用,并初步探讨了力学因素和生物学因素引起骨质疏松的机理。本论文包含两个主要部分。第一部分依据骨的功能适应性和力学调控系统理论,遵循骨重建的生理过程,提出一个带有时间历程的描述松质骨骨质疏松过程的计算模型,模拟了废用引起的骨质疏松,并讨论了峰值骨量对松质骨骨质疏松过程的影响。第二部分研究力学因素和生物学因素在松质骨骨质疏松过程中的作用。根据骨重建的生理过程,在基本多细胞单位(BMUs)层次建立了一个力学因素和生物学因素耦联的,带有时间历程的松质骨骨质疏松过程计算模型。通过载荷降低来模拟绝经期力学因素的变化,通过骨重建阈值的提高来模拟绝经期生物学因素的变化,量化了妇女绝经期骨量变化过程,分析表明:单独废用;单独骨重建阈值的提高;或二者共同作用都可以使模拟结果与Recker 等临床观测结果非常接近。并初步探讨了力学因素和生物学因素引起骨质疏松的机理。本论文的研究为骨质疏松的预防和治疗打下了理论基础,很具临床指导意义。
[Abstract]:Computer quantitative numerical simulation based on certain experiments is a hot issue at home and abroad. Based on the experimental results at home and abroad, a new quantitative calculation model of cancellous bone osteoporosis with time course coupled with biomechanical and biological factors was established in this paper. The mechanism of osteoporosis caused by mechanical and biological factors was also discussed. This thesis consists of two main parts. In the first part, according to the theory of functional adaptability and mechanical regulation system of bone, and following the physiological process of bone reconstruction, a computational model with time course was proposed to describe the process of osteoporosis of cancellous bone, and the osteoporosis caused by waste was simulated. The effect of peak bone mass on the process of cancellous bone osteoporosis was discussed. The second part studies the role of mechanical and biological factors in the process of cancellous bone osteoporosis. According to the physiological process of bone reconstruction, a computational model of cancellous bone osteoporosis with time course was established at the basic multicellular unit (BMUs) level, which was coupled with mechanical and biological factors. The changes of biomechanical factors in menopausal period were simulated by load reduction and biological factors of menopausal period were simulated by raising bone reconstruction threshold. The change process of bone mass in menopausal women was quantified. The increase of the threshold of bone reconstruction alone, or the combination of both, can make the simulated results very close to the clinical observations such as Recker. The mechanism of osteoporosis caused by mechanical and biological factors was also discussed. The research in this paper lays a theoretical foundation for the prevention and treatment of osteoporosis and has clinical significance.
【学位授予单位】：吉林大学
【学位级别】：博士
【学位授予年份】：2005
【分类号】：R311

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