脂多糖受体复合物基因多态性与感染易感性相关研究
发布时间：2019-01-30 09:48
【摘要】：背景和目的：目前对全身性感染及炎性反应的认识已有很大提高，医疗技术及医疗设备也有了很大提高，但是在全世界范围内，全身性感染(sepsis)仍是值得关注的问题：感染性休克的死亡率—这个重症监护病房最常见的死亡原因，并没有显著下降。约50％的全身性感染及感染性休克是革兰阴性杆菌所致。越来越多的证据表明遗传易感性与感染性疾病相关。遗传流行病学研究表明遗传因素对全身性感染的预后有重要影响。 基因的多态性即等位基因的变异，通常以一定频率存在于人群中，但不能用新的突变来解释(通常＞1％)。最常见的基因多态性是单核苷酸多态性(SNP)，，可以是替换、缺失或插入一个单核苷酸。人类DNA大约每300～500个碱基对就可能有一个SNP。变异的基因可以是在基因或启动子区的编码区(外显子)，也可以是非编码区(内含子)。当SNP发生在基因的蛋白编码区，等位基因的变异可以导致氨基酸的替换，最终可引起蛋白功能的变化，使不同基因型患者的感染易感性有显著差异。 脂多糖(LPS)是革兰阴性菌细胞外壁的主要成份，可引发系统性炎性反应，最终可能导致全身性感染、感染性休克和器官衰竭。因此，研究LPS受体复合物基因多态性与感染易感性的关系有着重要的临床意义。 目前已经认识到基因多态性可以解释为什么一小部分高危人群对抗生素无效或有药物毒性反应。明确全身性感染反应中的基因成份，有助于在治疗全身
[Abstract]:Background and objective: knowledge of systemic infection and inflammatory response has been greatly improved, medical technology and medical equipment have also been greatly improved, but worldwide, Systemic infection of (sepsis) remains a concern: the death rate from septic shock, the most common cause of death in intensive care units, has not declined significantly. About 50% of systemic infections and septic shock were caused by gram-negative bacilli. There is growing evidence that genetic predisposition is associated with infectious diseases. Genetic epidemiology has shown that genetic factors play an important role in the prognosis of systemic infection. The polymorphism of the gene is the variation of allele, which usually exists in the population at a certain frequency, but can not be explained by the new mutation (usually > 1%). The most common genetic polymorphisms are single nucleotide polymorphisms (SNP),) that can be replaced, deleted or inserted into a single nucleotide. Human DNA may have one SNP. for every 300-500 base pairs The mutated gene may be in the coding region (exon) or non-coding region (intron) of the gene or promoter. When SNP occurs in the protein coding region of the gene, allelic variation can lead to amino acid replacement, and eventually lead to the change of protein function, resulting in significant differences in susceptibility to infection in patients with different genotypes. Lipopolysaccharide (LPS) is the main component of the cell wall of gram-negative bacteria, which can induce systemic inflammatory reaction and may lead to systemic infection, septic shock and organ failure. Therefore, it is of great clinical significance to study the relationship between LPS receptor complex gene polymorphism and susceptibility to infection. Genetic polymorphisms have been recognized to explain why a small number of high-risk populations are ineffective or toxic to antibiotics. The identification of gene components in systemic infection response may be helpful in the treatment of systemic infection.
【学位授予单位】：第一军医大学
【学位级别】：硕士
【学位授予年份】：2006
【分类号】：R363
本文编号：2418009
[Abstract]:Background and objective: knowledge of systemic infection and inflammatory response has been greatly improved, medical technology and medical equipment have also been greatly improved, but worldwide, Systemic infection of (sepsis) remains a concern: the death rate from septic shock, the most common cause of death in intensive care units, has not declined significantly. About 50% of systemic infections and septic shock were caused by gram-negative bacilli. There is growing evidence that genetic predisposition is associated with infectious diseases. Genetic epidemiology has shown that genetic factors play an important role in the prognosis of systemic infection. The polymorphism of the gene is the variation of allele, which usually exists in the population at a certain frequency, but can not be explained by the new mutation (usually > 1%). The most common genetic polymorphisms are single nucleotide polymorphisms (SNP),) that can be replaced, deleted or inserted into a single nucleotide. Human DNA may have one SNP. for every 300-500 base pairs The mutated gene may be in the coding region (exon) or non-coding region (intron) of the gene or promoter. When SNP occurs in the protein coding region of the gene, allelic variation can lead to amino acid replacement, and eventually lead to the change of protein function, resulting in significant differences in susceptibility to infection in patients with different genotypes. Lipopolysaccharide (LPS) is the main component of the cell wall of gram-negative bacteria, which can induce systemic inflammatory reaction and may lead to systemic infection, septic shock and organ failure. Therefore, it is of great clinical significance to study the relationship between LPS receptor complex gene polymorphism and susceptibility to infection. Genetic polymorphisms have been recognized to explain why a small number of high-risk populations are ineffective or toxic to antibiotics. The identification of gene components in systemic infection response may be helpful in the treatment of systemic infection.
【学位授予单位】：第一军医大学
【学位级别】：硕士
【学位授予年份】：2006
【分类号】：R363
【引证文献】
相关博士学位论文 前1条
1 赵一萍;蒙古马免疫相关基因表达研究及脾脏表达谱分析[D];内蒙古农业大学;2013年
本文编号：2418009
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