小鼠免疫抑制性受体LAIR-1分子的分布及功能的研究
发布时间：2019-03-25 18:37
【摘要】：人白细胞相关免疫球蛋白样受体1(leukocyte-associated immunoglobulin-like receptor-1，LAIR-1)是1997年基因克隆成功的分子，在2004年底举行的第八届国际人类白细胞分化抗原大会上获准了新的CD编号(CD305)。自从1983年发现该分子以来，已证明其是与免疫功能密切相关的抑制性受体，能够抑制多种免疫细胞的功能。研究发现，LAIR-1具有广泛的组织分布，并在造血细胞的分化、增殖中起重要的调节作用，是一个具有重要生物学功能及临床潜在应用前景的分子。 小鼠LAIR-1(murine LAIR-1，mLAIR-1)是人LAIR-1(human LAIR-1，hLAIR-1)基因在小鼠体内的同源物，其序列在氨基酸水平与人LAIR-1分子有40％同源性，2002年我室首次从小鼠胸腺中成功克隆该基因(GenBankAF479685)。小鼠LAIR-1基因位于小鼠7号染色体上，共编码263个氨基酸，，胞膜外区也含有1个免疫球蛋白(Ig)样结构域，故属于免疫球蛋白超家族(IgSF)成员，胞质区含有2个ITIM(immunoreceptor tyrosine-based inhibitory motif)样基序。探讨LAIR-1在人与鼠表达的异同点，有助于对该分子生物学功能的进一步认识，也有助于了解其在生物进化过程中所发生的变化。本博士论文是基于hLAIR-1分子研究的基础上，对mLAIR-1分子的表达、分布及
[Abstract]:Human leukocyte-associated immunoglobulin-like receptor 1 (leukocyte-associated immunoglobulin-like receptor-1,LAIR-1) was successfully cloned in 1997. The new CD number (CD305) was approved at the eighth International Conference on Human Leukocyte differentiation Antigen, held at the end of 2004. Since its discovery in 1983, it has been proved to be an inhibitory receptor closely related to immune function, which can inhibit the functions of many immune cells. It has been found that LAIR-1 has a wide range of tissue distribution and plays an important role in regulating the differentiation and proliferation of hematopoietic cells. It is a molecule with important biological function and potential clinical application. Mouse LAIR-1 (murine LAIR-1,mLAIR-1) is a homologue of human LAIR-1 (human LAIR-1,hLAIR-1) gene in mice, and its sequence has 40% homology with human LAIR-1 at amino acid level. This gene (GenBankAF479685) was cloned successfully from mouse thymus for the first time in 2002. Mouse LAIR-1 gene, located on mouse chromosome 7, encodes a total of 263amino acids, and the extracellular domain also contains an immunoglobulin (Ig)-like domain, so it belongs to the (IgSF) member of immunoglobulin superfamily. The cytoplasmic region contained two ITIM (immunoreceptor tyrosine-based inhibitory motif)-like motifs. Discussing the similarities and differences of the expression of LAIR-1 in human and mouse is helpful to further understand the biological function of the molecule and to understand the changes of the molecular biological function in the process of biological evolution. This doctoral thesis is based on the study of hLAIR-1 molecules, the expression, distribution and distribution of mLAIR-1 molecules
【学位授予单位】：第四军医大学
【学位级别】：博士
【学位授予年份】：2006
【分类号】：R392
本文编号：2447210
[Abstract]:Human leukocyte-associated immunoglobulin-like receptor 1 (leukocyte-associated immunoglobulin-like receptor-1,LAIR-1) was successfully cloned in 1997. The new CD number (CD305) was approved at the eighth International Conference on Human Leukocyte differentiation Antigen, held at the end of 2004. Since its discovery in 1983, it has been proved to be an inhibitory receptor closely related to immune function, which can inhibit the functions of many immune cells. It has been found that LAIR-1 has a wide range of tissue distribution and plays an important role in regulating the differentiation and proliferation of hematopoietic cells. It is a molecule with important biological function and potential clinical application. Mouse LAIR-1 (murine LAIR-1,mLAIR-1) is a homologue of human LAIR-1 (human LAIR-1,hLAIR-1) gene in mice, and its sequence has 40% homology with human LAIR-1 at amino acid level. This gene (GenBankAF479685) was cloned successfully from mouse thymus for the first time in 2002. Mouse LAIR-1 gene, located on mouse chromosome 7, encodes a total of 263amino acids, and the extracellular domain also contains an immunoglobulin (Ig)-like domain, so it belongs to the (IgSF) member of immunoglobulin superfamily. The cytoplasmic region contained two ITIM (immunoreceptor tyrosine-based inhibitory motif)-like motifs. Discussing the similarities and differences of the expression of LAIR-1 in human and mouse is helpful to further understand the biological function of the molecule and to understand the changes of the molecular biological function in the process of biological evolution. This doctoral thesis is based on the study of hLAIR-1 molecules, the expression, distribution and distribution of mLAIR-1 molecules
【学位授予单位】：第四军医大学
【学位级别】：博士
【学位授予年份】：2006
【分类号】：R392
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相关期刊论文 前4条
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