味觉神经损伤与再生对动物味觉功能影响的研究进展

发布时间：2019-08-07 10:46

【摘要】：味觉的感受器是味蕾,来源于味蕾的味觉信号通过味觉神经传递到味觉中枢神经系统。鼓索神经和舌咽神经是支配舌面味蕾的两大主要味觉神经,它们分别支配着前舌和后舌的味蕾。味觉神经损伤可以引起所支配的味蕾萎缩、退化、消失,进而导致部分味觉功能受损,受损的味觉功能则可以在味觉神经再生后得到恢复。味觉神经交叉再生支配大鼠模型是研究中枢神经系统可塑性变化的重要平台。味觉神经交叉再生支配后,动物的行为学反应和味觉神经的电生理特性都发生了很大的变化。本文综述味觉神经损伤、再生以及味觉神经交叉支配对动物味觉功能的影响,并对味觉神经交叉再生支配动物模型以后的研究方向进行展望。味觉神经损伤、再生和交叉再生支配的研究不仅有助于揭示味觉神经系统可塑性变化的机制,也将为临床上寻找治疗味觉障碍患者的方法和技术提供理论基础和新的思路。
[Abstract]:The receptor of taste is taste bud, and the taste signal from taste bud is transmitted to taste central nervous system through taste nerve. Tympanic nerve and glossharyngeal nerve are the two main taste nerves that dominate the taste buds of the tongue surface, which dominate the taste buds of the front tongue and the posterior tongue, respectively. Taste nerve injury can cause the dominant taste buds to atrophy, degrade and disappear, which can lead to the damage of some taste function, and the damaged taste function can be recovered after the regeneration of taste nerve. The rat model of taste nerve cross regeneration innervates is an important platform to study the plasticity of central nervous system. After the cross regeneration of taste nerve, the behavioral response and electrophysiological characteristics of taste nerve changed greatly. In this paper, the effects of taste nerve injury, regeneration and taste nerve cross innervation on animal taste function were reviewed, and the future research direction of taste nerve cross regeneration innervation animal model was prospected. The study of taste nerve injury, regeneration and cross regeneration innervation will not only help to reveal the mechanism of the plasticity of taste nervous system, but also provide a theoretical basis and new ideas for finding clinical methods and techniques for the treatment of taste disorders.
【作者单位】：西安交通大学医学院生理学与病理生理学系;河南大学公共卫生研究所;
【基金】：supported by the National Natural Science Foundation of China(No.31371027) the Leading Edge Technology Research Program of Department of Science and Technology of Henan Province,China(No.132300410270)
【分类号】：R338

【共引文献】