Atoh1转录因子在耳蜗内的转译后调节（英文）
发布时间：2021-03-04 04:14
Atoh1属于bHLH转录因子家族成员,其对耳蜗毛细胞的胚胎发育及损伤后再生具有重要作用。许多讯号通道在转录水平上对Atoh1有调节作用,包括Notch和Wnt通道。在蛋白转译后水平,Atoh1是经由泛素-蛋白酶通道所调节。体外细胞实验及体内动物实验都显示:经由上述讯号通道的调节手段不仅影响耳蜗发育,也导致毛细胞的损伤后再生。本综述回顾了耳蜗内各个对Atoh1调节讯号通道研究的进展,并聚焦于泛素-蛋白酶通道对Atoh1进行转译后调节及其对毛细胞发育的影响。
【文章来源】：Journal of Zhejiang University-Science B（Biomedicine & Biotechnology）. 2019,20(02)
【文章页数】：10 页
【文章目录】：
1 Introduction
2 Hearing imààpccai22rment`àca22
3 Atoh1, a b HLH transcription factor, is required for hair cell differentiation and regeneration after damage
4 Atoh1 level is critical for hair cell devel-opment and regeneration in mice
5 Atoh1 is widely expressed
6 Signaling pathways that regulate Atoh1
6.1 Notch signaling pathway
6.2 Wnt/β-catenin signaling pathway
6.3 Post-translational regulation of Atoh1:the CK1-Huwe1-ubiquitin-proteasome pathway
7 Concluding remarks
Compliance with ethics guidelines
本文编号：3062544
【文章来源】：Journal of Zhejiang University-Science B（Biomedicine & Biotechnology）. 2019,20(02)
【文章页数】：10 页
【文章目录】：
1 Introduction
2 Hearing imààpccai22rment`àca22
3 Atoh1, a b HLH transcription factor, is required for hair cell differentiation and regeneration after damage
4 Atoh1 level is critical for hair cell devel-opment and regeneration in mice
5 Atoh1 is widely expressed
6 Signaling pathways that regulate Atoh1
6.1 Notch signaling pathway
6.2 Wnt/β-catenin signaling pathway
6.3 Post-translational regulation of Atoh1:the CK1-Huwe1-ubiquitin-proteasome pathway
7 Concluding remarks
Compliance with ethics guidelines
本文编号：3062544
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