胆系疾病与乙型肝炎病毒感染相关性研究

发布时间：2018-03-19 15:02

本文选题：乙型病毒性肝炎　切入点：乙型肝炎病毒　出处：《泰山医学院》2013年硕士论文　论文类型：学位论文

【摘要】：目的乙型病毒性肝炎（简称乙肝）系由乙型肝炎病毒（hepatitis virus B,HBV）所引起的一种肝脏疾病，主要经输血、注射和母婴传播。HBV属于独特的嗜肝DNA病毒，是已知真核细胞中最小的DNA病毒，结构紧凑，，功能齐全。乙肝常导致慢性感染，有15%～40%未经抗病毒治疗的患者将进展为终末期肝病，如肝硬化、肝衰竭及肝癌等。乙型肝炎病毒感染亦是一种全身性传染性疾病，胆囊与肝脏紧邻，肝脏分泌的胆汁在胆囊内贮存，胆囊有可能成为HBV侵犯的靶器官。胆系疾病以胆囊炎、胆石症多见，本课题以胆囊炎、胆石症做为主要研究对象；探讨胆系疾病与乙肝病毒感染的关系。方法随机抽取符合《外科学》(第7版)诊断标准的胆囊炎胆石症患者60例为胆系疾病组，均化验肝功能等指标，检测该组HBsAg的阳性率；另随机抽取我院2012年至2013年收住的非肝胆疾病患者60例作为对照组，收录标准：均行肝胆超声检查并化验肝功能、血凝等指标正常，检测该组HBsAg的阳性率，与胆系疾病组做比较。结果（1）胆系疾病组乙肝病毒感染率为70.0%，对照组乙肝病毒感染率达13.3%。（2）胆系疾病患者中乙肝的发生与ALT、BIL呈正相关，与A/G呈负相关。（3）胆系疾病合并乙肝患者男性多于女性。结论胆囊炎、胆石病的发生与乙肝病毒感染有明显的相关关系。
[Abstract]:Purpose. Hepatitis B virus (HBV) is a kind of liver disease caused by hepatitis B virus hepatitis B (HBV). It is mainly transfusions, injections and mother-to-child transmission. HBV belongs to the unique Hepatophilic DNA virus and is the smallest known DNA virus in eukaryotic cells. Hepatitis B often causes chronic infection. 15% of patients without antiviral treatment will progress to end-stage liver disease, such as liver cirrhosis, liver failure, liver cancer, etc. Hepatitis B virus infection is also a systemic infectious disease. The bile secreted by the liver is stored in the gallbladder and the gallbladder may become the target organ of HBV invasion. Cholecystitis and cholelithiasis are the common diseases of the gallbladder. Cholecystitis and cholelithiasis are the main research objects in this paper. To explore the relationship between biliary diseases and hepatitis B virus infection. Sixty patients with cholecystitis and cholelithiasis who met the diagnostic criteria of surgery (7th edition) were randomly selected as biliary disease group. The liver function was tested and the positive rate of HBsAg in this group was detected. From 2012 to 2013, 60 patients with non-hepatobiliary diseases were randomly selected as the control group. The criteria included: liver and bile ultrasound examination, liver function test, blood coagulation and other indexes were normal, the positive rate of HBsAg in this group was detected. A comparison was made with the group of biliary diseases. Results. 1) the infection rate of hepatitis B virus was 70.0 in the group of biliary diseases and 13.3in the control group. 2) the incidence of hepatitis B was positively correlated with alt BIL and negatively correlated with A / G in patients with biliary diseases. 3) there were more men than women in patients with biliary diseases complicated with hepatitis B. Conclusion. Cholecystitis, cholelithiasis and hepatitis B virus infection have obvious correlation.
【学位授予单位】：泰山医学院
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R512.62;R575.6

【参考文献】