自噬相关基因频率分布特征与肺结核相关性研究

发布时间：2018-03-19 15:37

本文选题：结核　切入点：肺　出处：《重庆医学》2017年22期 　论文类型：期刊论文

【摘要】：目的根据肺结核患者自噬相关基因(ATG)频率分布特征探讨ATG位点多态性与肺结核易感相关性。方法应用SequenomMassArray质谱阵列技术对202例肺结核患者(病例组)及222例健康体检者(对照组)ATG的18个单核苷酸多态性(SNP)位点进行基因分型,统计分析各位点基因型与肺结核易感相关性。结果在肺结核患者和对照组中,校正了性别、年龄等因素后,通过二元logistic回归分析发现ATG4A基因rs807185和rs5973822位点基因型和等位基因频率分布差异有统计学意义(P0.05)。通过体质量指数(BMI)分层分析,发现这一差异在高BMI人群中更为显著,且均有病例组人群分布频率低于对照组的表现,其余16个SNP位点差异均无统计学意义。结论 ATG4A基因rs5973822和rs807185位点多态性可能与肺结核易感性相关联,且在高BMI群体中差异更显著。
[Abstract]:According to the purpose of autophagy in patients with pulmonary tuberculosis (ATG) gene frequency distribution of ATG polymorphism and susceptibility to pulmonary tuberculosis. The correlation method using SequenomMassArray mass spectrometry arrays for 202 cases of pulmonary tuberculosis patients (case group) and 222 healthy subjects (control group) 18 ATG single nucleotide polymorphism (SNP) locus genotyping, statistical analysis of their genotypes and susceptibility to pulmonary tuberculosis. The correlation results in pulmonary tuberculosis patients and the control group, adjusted for sex, age and other factors, by two yuan logistic regression analysis showed that ATG4A gene rs807185 and rs5973822 genotype and allele frequency distribution was statistically significant (P0.05). The body mass index (BMI) layered analysis, found the difference in high in the population of BMI is more significant, and there are cases of group distribution frequency lower than the control group, the remaining 16 bits at SNP There was no significant difference between the two groups. Conclusion the polymorphism of rs5973822 and rs807185 loci in ATG4A gene may be associated with susceptibility to pulmonary tuberculosis, and the difference is more significant in high BMI population.

【作者单位】：重庆医科大学附属第二医院呼吸内科;重庆医科大学附属第一医院呼吸内科;重庆医科大学附属第二医院检验科;
【基金】：国家自然科学基金资助项目(81171628) 重庆市卫计委基金资助项目(2012-2-370)
【分类号】：R521

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