入境外籍人员抗-HCV、HCV-RNA与ALT相关性及监测分析
发布时间：2018-10-25 11:42
【摘要】：目的掌握四川口岸入境外籍人群HCV感染情况及流行病学特征。探讨广东、深圳、云南、四川、辽宁口岸2010-2012年入境外籍人员抗-HCV阳性人员的抗-HCV、HCV-RNA载量及ALT三者的相关性,对口岸入境外籍人员更科学合理有效地开展丙肝传染病监测起好指导作用。方法对2010-2012年监测的四川口岸入境外籍人群HCV阳性检出者流行病学资料进行统计学分析。收集五大国境口岸保健中心筛查的235例抗-HCV阳性的入境外籍人员血清样本,用酶联免疫吸附测定(ELISA)法进行抗-HCV复检,用实时荧光定量PCR法检测HCV-RNA,同时收集其丙氨酸氨基转移酶(ALT)检测数据。数据采用SAS 9.13处理。结果 2010-2012年监测的四川口岸入境外籍人群HCV感染率是2.8‰,51~60岁年龄组,来华留学人员感染率最高。收集的235例抗-HCV阳性入境外籍人员血清标本复检后231例阳性,4例阴性。检出HCV-RNA阳性131例(占56.7%),其中ALT异常89例(占67.9%)。100例HCV-RNA阴性中ALT异常25例(占25.0%)。随着HCV-RNA载量的升高,ALT异常率有增高趋势(χ2=44.75,P0.01)。同时,ALT的均值随HCV-RNA载量的增加而升高(r=0.973,P0.01)。结论 HCV-RNA检出率与方法学敏感性、HCV感染所处的临床阶段、抗病毒药物的应用密切相关。HCV-RNA载量与ALT水平呈明显相关性。入境外籍人群中51~60岁年龄组,来华留学人员阳性检出率最高,提示在今后口岸HCV防控与分子流行病学分析工作中,可考虑将其作为重点监测对象。
[Abstract]:Objective to understand the prevalence and epidemiological characteristics of HCV infection in foreign population at Sichuan Port. To explore the correlation among anti HCV load and ALT of foreign nationals in Guangdong, Shenzhen, Yunnan, Sichuan and Liaoning ports from 2010 to 2012. It plays a guiding role in developing surveillance of hepatitis C infectious disease more scientifically, reasonably and effectively for foreigners entering the port. Methods Epidemiological data of HCV positive people in Sichuan port from 2010 to 2012 were analyzed statistically. The serum samples of 235 foreign immigrants who were positive for anti-HCV were collected from five national border port health care centers. The serum samples of anti-HCV were re-examined by (ELISA) assay by enzyme-linked immunosorbent assay (Elisa). Real-time fluorescence quantitative PCR method was used to detect HCV-RNA, and (ALT) data of alanine aminotransferase were collected at the same time. The data were processed by SAS 9.13. Results the HCV infection rate of the foreign population in Sichuan port was 2.8 鈥，
本文编号：2293602
[Abstract]:Objective to understand the prevalence and epidemiological characteristics of HCV infection in foreign population at Sichuan Port. To explore the correlation among anti HCV load and ALT of foreign nationals in Guangdong, Shenzhen, Yunnan, Sichuan and Liaoning ports from 2010 to 2012. It plays a guiding role in developing surveillance of hepatitis C infectious disease more scientifically, reasonably and effectively for foreigners entering the port. Methods Epidemiological data of HCV positive people in Sichuan port from 2010 to 2012 were analyzed statistically. The serum samples of 235 foreign immigrants who were positive for anti-HCV were collected from five national border port health care centers. The serum samples of anti-HCV were re-examined by (ELISA) assay by enzyme-linked immunosorbent assay (Elisa). Real-time fluorescence quantitative PCR method was used to detect HCV-RNA, and (ALT) data of alanine aminotransferase were collected at the same time. The data were processed by SAS 9.13. Results the HCV infection rate of the foreign population in Sichuan port was 2.8 鈥，
本文编号：2293602
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