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维生素D缺乏性佝偻病与婴幼儿反复呼吸道感染的相关性研究

发布时间:2018-01-01 21:07

  本文关键词:维生素D缺乏性佝偻病与婴幼儿反复呼吸道感染的相关性研究 出处:《青岛大学》2013年硕士论文 论文类型:学位论文


  更多相关文章: 婴幼儿反复呼吸道感染 佝偻病 25-(OH)D 骨碱性磷酸酶(BALP)


【摘要】:目的探讨维生素D缺乏性佝偻病与婴幼儿反复呼吸道感染的临床关系。 方法选择2012年3月至2012年9月在费县人民医院儿科就诊的60例反复呼吸道感染的婴幼儿为观察组,同期在儿童保健门诊体检的60例相同年龄段的健康婴幼儿作为对照组,2组均取清晨空腹血进行血清骨碱性磷酸酶及25-(OH)D的检测,对两组数据进行统计学分析,观察佝偻病在反复呼吸道感染患儿及正常体检儿童中的患病率情况,从而探讨维生素D缺乏性佝偻病与婴幼儿反复呼吸道感染的关联性,并用维生素D及钙剂对佝偻病及其亚临床状态的患儿进行治疗,进行半年跟踪随访。 结果1对反复呼吸道感染组和正常健康体检儿组佝偻病患病率进行统计学处理,差异有显著性(x2=14.79,P0.01);RRI组和对照组维生素D缺乏亚临床状态发生率进行统计学处理,差异无显著性(x2=2.68,P0.05)。 2将两组BALP检测结果进行比较,RRI组BALP250U/L的比率明显高于对照组,对两者数据进行统计学处理,差异有显著性(x2=15.96,P0.01)。 3两组患儿25-(OH)D测试结果分析,RRI组25-(OH)D降低比率明显高于对照组,经统计学分析,两组数据差异有显著性(x2=14.79, P0.01)。 4反复呼吸道感染组佝偻病患儿和维生素D缺乏亚临床状态患儿均给予维生素D,半年后复查,其呼吸系统反复感染性疾病的发病率和治疗前相比,有明显减少。 结论1反复呼吸道感染组佝偻病患病率明显高于正常体检儿童组,即婴幼儿反复呼吸道感染与佝偻病具有临床关联性。 2积极防治佝偻病可以降低婴幼儿反复呼吸道感染的患病率。
[Abstract]:Objective to investigate the clinical relationship between vitamin D deficiency rickets and recurrent respiratory tract infection in infants. Methods 60 infants with recurrent respiratory tract infection from March 2012 to September 2012 in Fexian people's Hospital were selected as observation group. In the same period, 60 healthy infants of the same age were taken as the control group and fasting blood samples were taken to detect serum alkaline phosphatase and OHH D in the same period. The data of the two groups were statistically analyzed to observe the prevalence of rickets in children with recurrent respiratory tract infection and healthy children. The relationship between vitamin D deficiency rickets and recurrent respiratory tract infection in infants was discussed. The children with rickets and its subclinical status were treated with vitamin D and calcium, followed up for half a year. Results 1the prevalence rate of rickets in the recurrent respiratory tract infection group and the normal health check group was statistically analyzed, and the difference was significant (P 0.01). The incidence of subclinical status of vitamin D deficiency in RRI group and control group was statistically analyzed. There was no significant difference in subclinical status between RRI group and control group. 2Compared the results of BALP detection in the two groups, the ratio of BALP250U/L in the RRI group was significantly higher than that in the control group, and the two data were statistically processed. The difference was significant (P 0.01). 3The results of 25-OHH D test in the two groups were significantly higher than those in the control group (P < 0.05), and the decrease rate of OHH D in RRI group was significantly higher than that in the control group (P < 0.05). There was significant difference between the two groups (P < 0.01). 4 the children with rickets and subclinical status of vitamin D deficiency were given vitamin D in the group of repeated respiratory tract infection, and the incidence of recurrent infectious diseases of the respiratory system was compared with that before treatment. There is a marked decrease. Conclusion 1 the prevalence rate of rickets in recurrent respiratory tract infection group was significantly higher than that in normal children group, that is, there was a clinical correlation between recurrent respiratory tract infection and rickets in infants. 2 active prevention and treatment of rickets can reduce the prevalence of recurrent respiratory tract infection in infants.
【学位授予单位】:青岛大学
【学位级别】:硕士
【学位授予年份】:2013
【分类号】:R725.6;R723.2

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