法洛四联症患儿术前口服咪达唑仑、氯胺酮和右美托咪定的临床观察

发布时间：2018-01-28 01:13

本文关键词： 术前用药咪达唑仑氯胺酮右美托咪定法洛四联症　出处：《上海交通大学学报(医学版)》2017年01期 　论文类型：期刊论文

【摘要】：目的·比较法洛四联症患儿术前口服咪达唑仑、氯胺酮和右美托咪定的临床有效性与安全性。方法·择期行法洛四联症纠治术的60例患儿随机分为3组,分别给予口服咪达唑仑(0.5 mg/kg)、氯胺酮(5 mg/kg)和右美托咪定(5μg/kg),每组20例。观察并记录给药接受度,给药前及给药后不同时间点的心率(HR)、脉搏血氧饱和度(SpO_2)、镇静评分,用药30 min后的分离评分及静脉置管评分。结果·右美托咪定组给药接受度显著高于咪达唑仑组和氯胺酮组(P0.05),3组镇静起效时间的差异无统计学意义(P0.05)。氯胺酮组的分离满意率和置管满意率显著高于咪达唑仑组和右美托咪定组(P0.05)。与给药前基础值比较,3组患儿给药后各时点的HR、SpO_2均无明显变化(P0.05)。结论·术前口服咪达唑仑、氯胺酮和右美托咪定均可为法洛四联症患儿提供良好的镇静效果,口服氯胺酮患儿的分离满意率与置管满意率最高。
[Abstract]:Objective: to compare the clinical efficacy and safety of oral midazolam, ketamine and dexmetomidine in children with tetralogy of Fallot before operation. Methods: 60 children with tetralogy of Fallot were randomly divided into 3 groups. Oral midazolam 0.5 mg / kg, ketamine 5 mg / kg) and dexmetomidine 5 渭 g / kg were given to 20 patients in each group. HR, SPO _ 2, and sedation score were measured before and after administration of the drug at different time points. Results: the drug acceptance of dexmetomidine group was significantly higher than that of midazolam group and ketamine group (P 0.05). There was no significant difference in the onset time of sedation among the three groups (P 0.05). The satisfactory rate of separation and tube placement in ketamine group was significantly higher than that in midazolam group and dexmetomidine group (P 0.05). Compared with baseline values before administration. There was no significant change in HRN SpO2 at all time points after administration in the three groups. Conclusion: midazolam was taken orally before operation. Ketamine and dexmetidine can provide good sedation effect for tetralogy of Fallot. The satisfactory rate of separation and tube placement is the highest in children with oral ketamine.
【作者单位】：上海交通大学医学院附属上海儿童医学中心麻醉科;
【基金】：上海市浦东新区科技发展基金(PKJ2015-Y02)~~
【分类号】：R726.1
【正文快照】： 紫绀型先天性心脏病患儿的术前用药一直是临床的一1对象与方法个重要问题,使患儿能够平静地与父母分离、顺利完成静脉置管和麻醉诱导,且最大限度地减少血流动力学波动、1.1对象和分组避免氧饱和度急剧下降是我们对这类患儿应用术前用药的根本目的。本研究比较法洛四联症患

【相似文献】