甘肃某妇幼保健机构新生儿先天性心脏病现况分析

发布时间：2018-02-01 12:21

本文关键词： 先天性心脏病新生儿筛查影响因素　出处：《兰州大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:了解甘肃某妇幼保健机构新生儿先天性心脏病现况,探讨影响先天性心脏病发生的危险因素,评估其在先心病发生中的作用,为加强先天性心脏病的一级预防提供科学依据。方法:于2013年12月-2014年11月在甘肃某妇幼保健机构开展以超声心动图为依据的新生儿先天性心脏病筛查。调查问卷采用国家心血管中心设计的《新生儿先天性心脏病筛查表》。通过病例对照研究分析先天性心脏病的影响因素,将筛查中呈阳性的受试儿按照纳入与排除标准纳入病例组,最终病例组纳入筛查阳性的新生儿73例;按照产妇常住址、新生儿分娩时间进行1:1频数匹配,选取同期在该妇幼保健机构住院分娩的,母婴同室管理的正常新生儿作为对照组,最终对照组纳入73例正常新生儿。通过描述性方法描述新生儿先天性心脏病筛查结果。在病例对照研究中,两组间均衡性使用单因素方差分析和卡方检验进行评价,通过单因素Logistic回归分析先心病的影响因素。对单因素分析筛选出的有临床意义的影响因素,进行多因素Logistic回归分析。结果:在所有筛查的2148名新生儿中,筛查出不同类型的先心病阳性73例,筛查阳性率为3.40%。单因素分析结果显示,产妇孕期体重增加幅度、产妇配偶年龄大小、产妇是否曾流产、产妇孕期是否服用复合维生素这4个变量与先心病的发生有关联;多因素logistic回归分析结果表明:产妇孕期体重增加幅度高于正常、曾经流产是先心病的危险因素,产妇配偶年龄小于30岁、孕期服用复合维生素是先心病的保护因素。结论:本次筛查中新生儿先天性心脏病的现况与国内部分一致。产妇曾经流产、产妇孕期体重增加幅度高于正常是先心病的危险因素,产妇孕期服用复合维生素、产妇配偶年龄低于30岁是先心病的保护因素。
[Abstract]:Objective: to investigate the present situation of congenital heart disease (CHD) in neonates in a maternal and child health care institution in Gansu province, to explore the risk factors affecting the occurrence of congenital heart disease and to evaluate its role in the occurrence of congenital heart disease. To provide a scientific basis for strengthening primary prevention of congenital heart disease. Methods:. Neonatal congenital heart disease screening based on echocardiography was carried out in a maternal and child health care institution in Gansu province from December 2013 to November 2014. The questionnaire was designed by the National Cardiovascular Center. Screening table for congenital heart disease in newborn. The influencing factors of congenital heart disease were analyzed by case-control study. The positive infants were included in the case group according to the criteria of inclusion and exclusion, and 73 newborns with positive screening were included in the final case group. According to the usual address of the puerpera and the delivery time of the newborn, 1: 1 frequency match was carried out. The normal newborns who were in hospital and delivered in the same period in the maternal and child health care institution were selected as the control group. Finally, 73 normal newborns were included in the control group. The results of neonatal congenital heart disease screening were described by descriptive method. The equilibrium between the two groups was evaluated by univariate ANOVA and chi-square test. The influencing factors of congenital heart disease were analyzed by univariate Logistic regression analysis. Multivariate Logistic regression analysis was performed. Results: among all the 2 148 newborns screened 73 were positive for different types of congenital heart disease. The positive rate of screening was 3.40.The results of univariate analysis showed that the maternal weight increased during pregnancy, the age of the spouse, and whether the pregnant woman ever had an abortion. Whether pregnant women take multivitamin these four variables are related to the occurrence of congenital heart disease; The results of multivariate logistic regression analysis showed that the weight gain of pregnant women was higher than that of normal women, and abortion was the risk factor of congenital heart disease, and the age of spouses was less than 30 years old. Taking multivitamins during pregnancy is the protective factor of congenital heart disease. Conclusion: the present situation of congenital heart disease in newborns in this screening is consistent with that in China. Maternal weight gain was higher than normal during pregnancy is the risk factor of congenital heart disease. Taking multivitamin during pregnancy and the age of spouse under 30 is the protective factor of congenital heart disease.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R722.1

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