右美托咪定对儿童牙科日间全麻手术苏醒期躁动的影响

发布时间：2018-02-06 02:48

本文关键词： 右美托咪定日间手术儿童牙科全麻　出处：《华西口腔医学杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的将右美托咪定用于儿童牙科日间全麻手术的维持,探讨其对苏醒期躁动发生的影响。方法将拟全麻下行口腔治疗的80例儿童牙科患儿随机分为A组和B组,每组40例。A组在全麻维持期静脉注射1μg·kg-1负荷量右美托咪定(生理盐水稀释至10 m L),然后以0.1~0.4 m L·(kg·h)-1的速度静脉注射至手术结束前45 min,B组以同样方式注射生理盐水。记录2组患儿的年龄,性别,体重,美国麻醉医师协会病情分级(ASAPS),不同时间点的心率(HR)、平均动脉压(MAP)、氧饱和度(Sp O2),舒芬太尼用量,手术持续时间,手术结束到拔管的时间,拔管到清醒的时间、清醒后行为评分(FPAS),达离院标准的时间等指标,并进行统计分析。结果 2组手术开始、手术10 min、30 min、1 h、2 h及拔管后的HR、MAP均有统计学差异,A组低于B组(P0.05);舒芬太尼用量及苏醒期躁动率也有统计学差异,A组低于B组(P0.05);2组拔管到清醒的时间及达离院标准的时间为A组长于B组(P0.05)。其他指标2组均无统计学差异。结论右美托咪定用于儿童牙科日间全麻手术,能降低苏醒期躁动发生率,术中生命体征更平稳。
[Abstract]:Objective to use dexmetidine in maintenance of children with day general anesthesia. Methods 80 cases of children dental children undergoing oral treatment under general anesthesia were randomly divided into group A and group B. Each group (40 cases) received intravenous injection of 1 渭 g 路kg-1 load of dexmetidine (diluted to 10 mL with normal saline) during the maintenance period of general anesthesia. Then, 0.4 mL 路kg 路h ~ (-1) of 0.1 渭 m 路L ~ (-1) 路h ~ (-1) was injected intravenously into group B 45 min before the end of operation. The age and sex of the children in the two groups were recorded. Body weight, ASAPS, mean arterial pressure MAPP, oxygen saturation, sufentanil dosage. The duration of operation, the time from the end of operation to extubation, the time from extubation to waking, the behavior score after waking up to FPASA, the time to reach the standard of leaving hospital, etc. Results there were significant differences in HRMAP between the two groups at the beginning of operation, 10 min to 30 min, 1 hour and 2 h after extubation. Group A was lower than group B (P 0.05); There were statistical differences in the dosage of sufentanil and the restlessness rate during the recovery period. The level of sufentanil in group A was lower than that in group B (P 0.05). The time between extubation and sobriety and the time to reach the hospital standard in group A was longer than that in group B (P 0.05). There was no significant difference in other indexes between the two groups. Conclusion dexmetomidine is used in general anesthesia in children's dentistry. It can reduce the incidence of restlessness during recovery period, and the vital signs are more stable during operation.
【作者单位】：口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院麻醉科;口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院儿童口腔科;
【基金】：国家临床重点专科建设项目(004030540-1313)~~
【分类号】：R726.1

【相似文献】