急性主动脉夹层患者血清儿茶酚胺质量浓度与氧合指数的相关性研究

发布时间：2018-02-10 12:58

本文关键词： 急性主动脉夹层儿茶酚胺氧和指数内毒素　出处：《四川大学学报(医学版)》2017年01期 　论文类型：期刊论文

【摘要】：目的探索急性主动脉夹层(acute aortic dissection,AAD)患者是否存在血清儿茶酚胺质量浓度的升高,以及患者血清儿茶酚胺质量浓度与氧合指数(oxygenation index,OI)的关系。方法 2013年4~12月期间,纳入3组患者(A组38例AAD患者、B组28例升主动脉瘤患者、C组22例心绞痛患者)为研究对象,收集所有患者一般临床资料,测定OI并采集血液标本测定肾上腺素(adrenaline,AD)、去甲肾上腺素(noradrenaline,NA)、内毒素(endotoxin,ET)的血清质量浓度。通过对3组患者上述指标的对比分析,观察AAD患者血清儿茶酚胺质量浓度是否升高;采用直线相关分析AAD患者血清儿茶酚胺质量浓度与ET质量浓度以及OI的关系。结果 3组患者一般临床资料差异无统计学意义。A组患者血清AD、NA、ET质量浓度均高于B组和C组(P0.001),OI低于B组和C组(P0.001)。采用直线相关分析发现AAD患者血清AD及NA质量浓度均与ET质量浓度存在正相关性,而与OI呈负相关性。结论血清儿茶酚胺浓度的升高可能与AAD患者急性肺损伤有关。
[Abstract]:Objective to explore the relationship between serum catecholamine concentration and oxygenation index (Oi) in patients with acute aortic dissection of acute aortic dissection (AAD). The study included 38 patients with AAD in group A, 28 patients with ascending aortic aneurysm in group B and 22 patients with angina pectoris in group C. The serum concentrations of adrenocephalin, noradrenaline, endotoxin and endotoxin in patients with AAD were measured, and the serum catecholamine concentrations in AAD patients were observed by comparing and analyzing the above indexes. Linear correlation analysis was used to analyze the relationship between serum catecholamine concentration and et concentration and OI in AAD patients. Results there was no significant difference in general clinical data among the three groups. P0.001OI in group C and group C were lower than those in group B and group C. the linear correlation analysis showed that there was a positive correlation between serum AD and na concentration and et concentration in patients with AAD. Conclusion the increase of serum catecholamine concentration may be related to acute lung injury in patients with AAD.
【作者单位】：四川大学华西医院心血管外科;四川大学华西医院麻醉科;
【分类号】：R543.1

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