婴幼儿喘息患者外周血Th17细胞比例、血清IL-17水平变化及其意义

发布时间：2018-02-16 12:58

本文关键词： 婴幼儿喘息辅助性T细胞白细胞介素哮喘预测指数　出处：《山东医药》2017年23期 　论文类型：期刊论文

【摘要】：目的探讨婴幼儿喘息患者外周血Th17细胞比例、血清IL-17水平变化及其意义。方法选择42例婴幼儿喘息患儿为喘息组(其中哮喘预测指数阳性22例、哮喘预测指数阴性20例),20例同年龄段非喘息性支气管肺炎患儿为非喘息组,20例无肺部感染患儿为对照组。采用流式细胞仪和流式细胞术测算各组患儿外周血中Th17细胞比例,采用ELISA法检测外周血清IL-17水平。结果哮喘预测指数阳性组、哮喘预测指数阴性组、非喘息组、对照组患儿外周血Th17比例分别为14.12%±2.64%、6.18%±1.12%、1.91%±0.93%、0.69%±0.32%。喘息组患儿外周血Th17比例高于非喘息组及对照组(P0.05)。喘息组哮喘预测指数阳性、阴性患儿外周血Th17比例相比,P0.05。哮喘预测指数阳性组、哮喘预测指数阴性组、非喘息组、对照组患儿外周血清IL-17水平分别为(180.55±18.12)、(132.56±10.53)、(118.45±8.16)、(85.21±6.03)pg/mL,喘息组患儿外周血清IL-17水平高于非喘息组(P0.05),喘息组哮喘预测指数阳性、阴性患儿外周血清IL-17水平相比,P0.05。结论婴幼儿喘息患者外周血Th17细胞比例、血清IL-17水平升高,且与哮喘预测指数有关。检测婴幼儿喘息患者外周血Th17细胞比例、血清IL-17水平有助于预测患者的转归。
[Abstract]:Objective to investigate the proportion of Th17 cells in peripheral blood of patients with wheezing, change and clinical significance of serum IL-17 level. Methods 42 cases of infant wheezing wheezing group (including asthma predictive index was positive in 22 cases, 20 cases of asthma predictive index negative), 20 cases of the same age in non asthmatic bronchial pneumonia in children with non wheezing group, 20 no cases of pulmonary infection in children as control group. The percentage of Th17 cells by flow cytometry and flow cytometry were measured in peripheral blood were detected by ELISA in peripheral serum IL-17 level. Results the Asthma Predictive Index of asthma predictive index positive group, negative group, non wheezing group, the proportion of Th17 in peripheral blood of the patients in the control group outside were 14.12% + 2.64%, 6.18% + 1.12%, 1.91% + 0.93%, Th17 + 0.32%. ratio in peripheral blood of 0.69% children with wheezing group than non asthmatic group and control group (P0.05 group). Wheezing Asthma Predictive Index positive and negative in peripheral blood of children with Th1 The proportion of 7 compared to P0.05., the Asthma Predictive Index of asthma predictive index positive group, negative group, non wheezing group, control group with peripheral serum levels of IL-17 were (180.55 + 18.12), (132.56 + 10.53), (118.45 + 8.16), (85.21 + 6.03) pg/mL, wheezing group with peripheral serum IL-17 level higher than the non wheezing group (P0.05), asthmatic group Asthma Predictive Index of positive and negative group, peripheral serum IL-17 levels compared to P0.05. conclusion wheezing in patients with peripheral blood Th17 cell percentage, serum IL-17 levels were increased, and the index associated with asthma prediction. The detection ratio of infant wheezing in patients with peripheral blood Th17 cells, serum IL-17 level is helpful to predict patient outcome.

【作者单位】：徐州医科大学附属医院;
【分类号】：R725.6

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