中山市2011-2015年儿童手足口病流行病学调查及分子病原学研究

发布时间：2018-02-21 12:45

本文关键词： 手足口病实时荧光定量PCR 柯萨奇病毒A型肠道病毒型流行病学　出处：《实用医学杂志》2017年11期 　论文类型：期刊论文

【摘要】：目的:研究中山市2011-2015年儿童手足口病流行特征,为防控儿童手足口病的发生提供依据。方法:回顾性分析中山市博爱医院2011-2015年手足口病患儿临床资料,及其肠道病毒核酸检测结果。结果:2011-2015年共诊断手足口病患儿31 164例,男女比例为1.62∶1。每年发病的高峰不尽相同。共收集手足口病患儿标本10 147例进行EV71和Cox A16检测,检出阳性2 062例,总阳性率为20.32%。2011-2013年、2015年手足口病病原体主要以EV71为流行趋势,分别占当年总阳性的79.04%、72.46%、81.60%、73.73%;2014年手足口病病原体主要以Cox A16为流行趋势,占当年总阳性的54.47%。不同年份间EV71和Cox A16阳性差异有统计学意义。重复感染手足口病患儿有1 982例,占6.36%。结论:中山市儿童手足口病的发病与年龄、性别、季节有关,病例主要以临床诊断为主,给出针对性的预防措施和及时的临床识别,将有助于儿童手足口病的治疗和控制。
[Abstract]:Objective: to study the epidemic characteristics of hand, foot and mouth disease (HFMD) in children from 2011 to 2015 in Zhongshan City, and to provide evidence for the prevention and control of HFMD in children. Methods: the clinical data of children with HFMD from 2011 to 2015 in Boai Hospital of Zhongshan City were retrospectively analyzed. Results from 2011 to 2015, 31,164 children with hand-foot-mouth disease were diagnosed, the ratio of male to female was 1.62: 1.The peak incidence of HFMD was different every year. 10 147 samples of HFMD were collected for EV71 and Cox A16 detection. The total positive rate was 20.32.2011-2013. In 2015, EV71 was the main pathogen of HFMD, accounting for 79.04% of the total positive in that year and 72.46% of the total positive in that year. In 2014, Cox A16 was the main pathogen of HFMD. There were significant differences between EV71 and Cox A16 positive in different years. There were 1 982 cases of hand, foot and mouth disease with repeated infection, which accounted for 6.360.Conclusion: the incidence of HFMD in children in Zhongshan City is related to age, sex and season. It is helpful to treat and control hand, foot and mouth disease in children.
【作者单位】：中山市博爱医院检验科;广东医科大学;
【分类号】：R181.3;R725.1

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