玉屏风颗粒防治气虚体质小儿反复上呼吸道感染临床观察

发布时间：2018-02-22 09:44

本文关键词： 玉屏风颗粒体质反复上呼吸道感染疗效　出处：《广州中医药大学》2014年硕士论文　论文类型：学位论文

【摘要】：研究背景：近些年不少儿科医师选用口服中成药“玉屏风颗粒”辅助治疗小儿反复上呼吸道感染,不但在临床上取得较好的疗效,又避免了中药饮片制剂口服方式的不足,因而在临床上得到不断地推广。“玉屏风颗粒”作为中药成药制剂,治疗也应遵循中医辨“质”论治理论,但其药物说明却缺少相应的中医体质类型,古往今来玉屏风散是治疗气虚外感的代表方剂,而气虚体质在小儿反复上呼吸道感染中最为常见,所以观察玉屏风颗粒防治气虚体质小儿反复上呼吸道感染的疗效是急需解决的问题。研究目的：通过观察玉屏风颗粒防治疗气虚体质小儿反复上呼吸道感染的疗效,以期为提高玉屏风颗粒临床用药的疗效和安全性提供依据。研究方法：选取符合本研究纳入标准的小儿120例,根据随机方法将其分为试验组和对照组,其中每组各60例,试验组和对照组均给予“对症治疗”,包括：如退热处理、止咳化痰、补液等治疗,在有细菌感染的情况下,可给与抗生素治疗(常规抗生素的使用对本病的病程并无影响《儿科学》)；试验组在取得患儿家长知情同意的情况下,在对症治疗的基础上(上呼吸道感染恢复期)加用玉屏风颗粒(广东环球制药有限公司,国药准字Z10930036)联合治疗。玉屏风颗粒(参考玉屏风颗粒说明书和文献资料)拟用法用量[1-3]如下：1-3岁,每次口服1／2包,3岁,每次口服1包,均3次／日,用开水冲服,连续服用1个月。治疗开始前进行基线资料分析,包括临床资料(性别、年龄、体重)、入院前病程、发病次数、免疫方面(IgA、IgG、IgM)以及证候积分等方面。疗效主要从患儿服用玉屏风颗粒1个月之后半年内的临床病程、发病次数、证候积分及症状等进行观察和判断,观察结束后进行统计数据的处理,此次统计学分析所用软件为SPSS16.0。研究结果： 1、通过统计分析,试验组和对照组的总有效率都得到了较理想的结果(分别为96.67%和83.33%),相比较而言,试验组的总有效率更高,两组经统计学分析后有明显差异(p0.05)； 2、两组中医证候积分方面的差异也具有统计学意义(p0.01)； 3、两组在患病的次数、病程,症状体征的改善方面差异显著(p0.01)； 4、另外免疫功能方面(特别是IgA、IgG)两组在治疗后差异也是比较明显的(p0.01),说明玉屏风颗粒在免疫系统的调节方面也发挥了重要作用。研究结论： 1、玉屏风颗粒联合对症治疗对气虚体质小儿反复上呼吸道感染的疗效优于单纯对症治疗；2、玉屏风颗粒具有提高机体免疫功能的作用；3、玉屏风颗粒在此次研究过程中无明显不良反应,安全性良好,适合临床推广应用。
[Abstract]:Background:. In recent years, many pediatricians have used oral Chinese patent medicine "Yuping Feng granule" to assist in the treatment of recurrent upper respiratory tract infections in children, which has not only achieved good clinical results, but also avoided the shortage of oral oral methods of Chinese herbal medicine. Therefore, it has been popularized in clinic. As a traditional Chinese medicine preparation, the treatment of Yupingfeng granule should also follow the theory of "quality" of TCM, but its drug description lacks the corresponding TCM physique type. Yupingfeng Powder is a representative prescription for the treatment of Qi deficiency, and Qi-deficiency constitution is most common in children with recurrent upper respiratory tract infection. So it is urgent to observe the curative effect of Yupingfeng granule in preventing and treating recurrent upper respiratory tract infection in children with deficiency of qi. Objectives of the study:. In order to improve the efficacy and safety of Yupingfeng granule in the treatment of recurrent upper respiratory tract infection in children with deficiency of qi, the therapeutic effect of Yupingfeng granule was observed. Research methods:. 120 children who met the criteria of this study were randomly divided into two groups: the experimental group (n = 60) and the control group (n = 60). The experimental group and the control group were given "symptomatic treatment", including: antipyretic treatment, cough and phlegm control. In the case of bacterial infection, antibiotics can be given (the use of routine antibiotics has no effect on the course of the disease; the experimental group has obtained the informed consent of the child's parents. Add Yupingfeng granules (Guangdong Global Pharmaceutical Co., Ltd.) on the basis of symptomatic treatment (upper respiratory tract infection recovery period), The dosage of Yupingfeng granules (with reference to the description of Yupingfeng granules and literature) [1-3] was as follows: 1 to 3 years old, 1/2 packets per oral for 3 years old, 1 packet for each time, 3 times a day, with boiling water, Baseline data were analyzed before treatment, including clinical data (sex, age, body weight, course of disease before admission, frequency of onset). The curative effect was mainly observed and judged from the clinical course, frequency of onset, syndromes and symptoms of the children within half a year after taking Yupingfeng granule for one month. The statistical data were processed after observation. The software used in the statistical analysis was SPSS 16. 0. Results of the study:. 1. Through statistical analysis, the total effective rate of the test group and the control group were all satisfactory (96.67% and 83.33, respectively). Compared with the control group, the total effective rate of the test group was higher, and there was a significant difference between the two groups after statistical analysis. 2, the difference of TCM syndromes integral between the two groups also has statistical significance. (3) there was significant difference between the two groups in the improvement of the frequency, course of disease, symptoms and signs of the disease (p 0.01). 4. In addition, the difference of immunological function between the two groups (especially IgA + IgG) after treatment is also obvious, indicating that Yupingfeng granule also plays an important role in the regulation of immune system. The study concluded that:. 1. The curative effect of Yupingfeng granule combined with symptomatic treatment on Qi-deficiency children with recurrent upper respiratory tract infection is better than that of simple symptomatic treatment. Yupingfeng granule has the effect of improving the immune function of the body. Yupingfeng granule is in the course of this study. There were no significant adverse reactions, It is safe and suitable for clinical application.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R272

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