托特罗定联合清洁间歇导尿和夜间留置导尿治疗儿童神经源性逼尿肌过度活动疗效分析

发布时间：2018-02-26 11:32

本文关键词： 儿童神经源性逼尿肌过度活动托特罗定导尿尿动力学检查　出处：《郑州大学学报(医学版)》2017年06期 　论文类型：期刊论文

【摘要】：目的:评估托特罗定联合清洁间歇导尿(CIC)和夜间留置导尿(CDN)治疗儿童神经源性逼尿肌过度活动(NDO)临床疗效。方法:选取(7.9±2.5)岁NDO患儿44例,按单盲、随机法分为观察组24例(托特罗定联合CIC和CDN治疗)和对照组20例(安慰剂联合CIC和CDN治疗),疗程4周。服药前和治疗4周后分别行尿动力学检查和记录3 d排尿日记。结果:共41例患儿完成4周治疗。观察组治疗后首次逼尿肌收缩时容量、膀胱安全容量、膀胱顺应性及每次导尿量较治疗前增大,24 h尿失禁次数减少(P0.05);对照组治疗后膀胱安全容量、膀胱顺应性较治疗前增大(P0.05);治疗后观察组首次逼尿肌收缩时容量、膀胱安全容量、膀胱顺应性、每次导尿量及24 h尿失禁次数的改善情况均好于对照组,差异有统计学意义(P0.05)。结论:托特罗定联合CIC和CDN治疗儿童NDO安全有效,可明显减少患儿尿失禁次数,改善患儿生活质量。
[Abstract]:Objective: to evaluate the clinical effect of tolterodine combined with clean intermittent catheterization (NDO) and nocturnal indwelling catheterization (CDN) in the treatment of neurogenic detrusor hyperactivity (NDOO) in children. The study group (24 cases) were randomly divided into two groups (Totterodine combined with CIC and CDN) and control group (20 cases) treated with placebo combined with CIC and CDN for 4 weeks. Before and after 4 weeks of treatment, urodynamic examination was performed and 3-day row was recorded, respectively. Results: a total of 41 children were treated for 4 weeks. The volume of detrusor contraction in the observation group was the first time after treatment. The safe volume of bladder, bladder compliance and the quantity of urinary catheterization were decreased by 24 h urinary incontinence compared with that before treatment, while in the control group, the safe volume of bladder and bladder compliance were increased after treatment, and the volume of the first detrusor contraction was increased in the observation group after treatment, and there was no significant difference between the treatment group and the control group in the first time of detrusor contraction. The improvement of bladder safety capacity, bladder compliance, urinary volume per catheterization and 24 h urinary incontinence was better than that in control group (P 0.05). Conclusion: Totrodine combined with CIC and CDN is safe and effective in the treatment of NDO in children. It can obviously reduce the number of urinary incontinence and improve the quality of life.
【作者单位】：郑州大学第一附属医院小儿尿动力学中心和泌尿外科;
【基金】：国家自然科学基金项目81670689
【分类号】：R726.9

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